Do not vaccinate animals less than 4 weeks before mating. Do not vaccinate pregnant animals. Do not vaccinate animals which are being treated with antimicrobial agents, particularly tetracyclines.
Special warnings for each target species
Chlamydophila abortus is only one of the causes of abortion in sheep. If abortion rates remain unchanged in flocks which have been vaccinated with CEVAC® CHLAMYDIA it is recommended that veterinary advice is sought. The epidemiology of abortion due to Chlamydophila abortus in ewes involves a long incubation period. Ewes that abort in any lambing season have usually been infected at the previous lambing. Field trial data indicate that vaccinating incubating ewes will reduce the incidence of abortion, but a proportion can still go on to abort. Care should be taken in handling such abortions as susceptible humans may be at risk of infection.
A transient temperature rise may be observed after vaccination (average of 1.5°C for a maximum of 3 days). In very rare cases abortions may occur where the vaccine strain can be identified. In very rare cases the vaccine may cause hypersensitivity reactions.
No particular signs at ten times dose other than a transient temperature increase as seen with a single dose.
Safety and efficacy data are available which demonstrate that this vaccine can be administered the same day but not mixed with a commercial Toxoplasma gondii vaccine containing live tachyzoites of the S48 strain. No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the products mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Do not mix with any other veterinary medicinal product, except diluent supplied for use with the product.
Special precautions to be taken by the person administering the product to animals
CEVAC® CHLAMYDIA should not be handled by pregnant women or women of child bearing age as the vaccine may cause abortion. CEVAC® CHLAMYDIA should not be handled by persons who are immune-deficient (e.g. AIDS sufferers, persons undergoing chemotherapy or taking immune-suppressive drugs) If in any doubt, you should consult your GP.
Operators should wear gloves when handling the vaccine.
Care should be taken to avoid self-injection, but if this occurs, immediate medical advice should be sought and the doctor informed that self injection with a living Chlamydophila vaccine has occurred. Tetracycline therapy is the current recognised treatment for infection with Chlamydophila abortus in humans.
Dispose of waste material by boiling, incineration or immersion in an appropriate disinfectant approved for use by the competent authorities.