Pharmacotherapeutic group: Procaine, combinations.
ATCvet code: QN01BA52
Pharmacodynamic properties
Procaine hydrochloride is a local anaesthetic.
Pharmacokinetic properties
The in vitro half-life in plasma is less than 1 minute. It is only slightly bound to plasma protein (5.8 %) and has a duration of anaesthetic effect of about 50 minutes in man. The addition of adrenaline to procaine causes a prolongation of local effect by vasoconstriction. The longer action is accompanied by a significant decrease in systemic toxicity, since the rate of hydrolysis exceeds the rate of absorption into the systemic circulation. The recommended level of adrenaline is 1 in 50,000; higher concentrations may cause tissue damage.