Pharmacodynamic properties
Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms.
The tylosin spectrum of activity includes Gram-positive bacteria, some Gram – negative strains such as Pasteurella, and Mycoplasma spp.
Pharmacokinetic properties
Absorption: tylosin reaches maximal blood levels between 1 and 3 hours after an oral dose.
Distribution: after oral doses were given to pigs, tylosin was found in all tissues between 30 minutes and 2 hours after administration, except for the brain and spinal cord. Compared to plasma levels clearly higher tissue concentrations have been observed.
Metabolism and excretion: most of the material excreted through the faeces consists of tylosin (factor A), relomycine (factor D) and dihydrodesmycosin.