Pharmacotherapeutic group: antibacterials for systemic use, macrolides,
ATC vet code: QJ01FA90
Pharmacodynamic properties
Tylosin is a macrolide antibiotic produced by a strain of Streptomyces fradiae. It exerts its antimicrobial effect by inhibiting protein synthesis of susceptible micro-organisms.
The tylosin spectrum of activity includes Gram-positive bacteria, some Gram – negative strains such as Pasteurella, and Mycoplasma spp. at concentrations of 16µg/ml or less.
Pharmacokinetic properties
In most species peak plasma concentrations have been attained 1 to 2 hours after administration of tylosin. Compared to plasma levels clearly higher tissue concentrations have been observed. Tylosin was extensively metabolized. Most of the residues are excreted in faeces predominantly consisting of tylosin A, tylosin factor D and dihydrodesmycosin.