Target species
Cattle (pregnant females).
Indications for use
For administration to pregnant cows and heifers to stimulate serological and colostral antibodies against rotavirus and coronavirus antigens and against K99, Y, 31A and F41 antigens of Escherischia coli in susceptible animals, which may be passed to the calf to reduce neonatal diarrhoea infection caused by agents containing these antigens.
Contra-indications
None.
Special warnings for each target species
None.
Special precautions for use
None.
Adverse reactions
Local reaction at the site of injection (≤10 cm), may appear after vaccination. This usually disappears within 14 days.
A slight increase in mean rectal temperature (≤0.5 °C) may be observed on the day following the injection.
Any injection of bacterial cells, even inactivated, may occasionally cause hypersensitivity reactions. In such cases, a symptomatic treatment should be provided.
Use during pregnancy, lactation or lay
For vaccination of pregnant cattle.
Interactions
No information is available on the safety and efficacy from the concurrent use of this vaccine with any other. Therefore the safety and efficacy of this product when used with any other (either when used on the same day or at different times) has not been demonstrated.
Amounts to be administered and administration route
Shake well before use. Subcutaneous route. Inject one 5 ml dose according to the following schedule:
Primary vaccination:
- First injection 1 to 2 months before calving.
- Second injection 2 to 4 weeks after first injection, at least 2 weeks prior to calving.
Boosters:
No data has been provided to support the use of a single dose booster regime. However, experience in the field suggests that a single dose of the vaccine administered two weeks before calving may provide enhanced antibody levels in the colostrum against the component antigens. Ensure that each calf rapidly ingests a sufficient quantity of colostrum.
Overdose
After administration of a double dose of vaccine, a local reaction at the site of injection may appear as a slight oedema evolving to a firm swelling, usually disappearing within 14 days of vaccination. A slight transient temperature rise (mean 0.7 °C) may be observed for two days following the injection.
Withdrawal periods
Zero days.