Target species
Chickens (future layers).
Indications for use
Active immunisation of future layers to reduce airsacculitis and tracheitis lesions caused by Mycoplasma gallisepticum.
Immunity develops within 4 weeks after vaccination. A duration of immunity of 24 weeks after vaccination was established using a typical batch containing 7.5 log10 CFU.
Contraindications
Not to be used within four weeks of onset of egg production or during lay. Not intended for future breeders.
Special warnings for each target species
Do not use antibiotics or other substances with any antimicrobial activity known to inhibit M. gallisepticum.
Special precautions for use
Vaccinate healthy chickens only. It is not recommended to vaccinate in the presence of (sub-) clinical infection with M. gallisepticum.
After vaccination the vaccine strain Mycoplasma gallisepticum MG 6/85 can be isolated in birds for at least 15 weeks. Care should be taken to prevent spread of the vaccine strain to other birds than chicken and turkeys, such as game birds, geese and ducks. Seroconversion may occur after vaccination.
The vaccine strain can be differentiated from wild Mycoplasma gallisepticum based on routine DNA analysis.
Operator warnings
To avoid skin and eye injuries as well as inhalation or digestion, personal protective equipment consisting of a mask, gloves and eye protection should be worn when handling the veterinary medicinal product. Wash and disinfect hands after vaccinating.
Adverse reactions
None.
Use during pregnancy or lactation
Not to be used within four weeks of onset of egg production or during lay. Not intended for future breeders.
Interactions
Safety and efficacy data are available which demonstrate that this vaccine can be mixed and administered with Nobilis MS Live (in member states where this product is authorized). The product literature of Nobilis MS Live should be consulted before administration of the mixed product. The mixed product is not to be used within four weeks of onset of egg production or during lay. The adverse effects observed after administration of one dose or an overdose of Nobilis MG 6/85 and Nobilis MS Live are not different from those described for Nobilis MG 6/85 alone. When mixed with Nobilis MS Live, the demonstrated efficacy claims are comparable to those described for Nobilis MG 6/85 alone.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Amounts to be administered and administration route
After reconstitution, administer 1 dose of vaccine by nebulisation (fine-spray) to chickens (future layers) from 6 weeks of age.
Use the entire contents when first opened.
Preparation of vaccine
1Use only clean, cool, non-chlorinated, preferably distilled water of ≤ 25 °C. The volume of water for reconstitution should be sufficient to ensure an even distribution when sprayed onto the birds. This will vary according to the size of the birds being vaccinated and the management system, but 250 to 400 ml of water per 1000 doses is recommended. Follow the instructions of the fine-spraying device.
2Open the vial submerged under water.
3Remove the seal and stopper from the vial.
4In case of mixed-use, repeat steps 2 and 3 in the same water using a vial of Nobilis MS Live containing the same number of doses.
Administration
- Vaccinate with a fine-spraying device suitable for nebulization application of vaccines (particle size: < 100 μm). The vaccine suspension should be spread evenly over the correct number of birds, at a distance of approximately 40 cm.
- Do not use any disinfectants, skimmed milk or other agents impairing the performance of the vaccine in the fine-spraying device.
- Shut off all fans and close air-inlets while fine-spray vaccinating.
- Clean the fine-spraying device thoroughly after use according to the manufacturer’s recommendation.
Overdose
Ten times a maximum dose is safe for the target species.
Withdrawal period
Zero days.