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Date: Thursday, July 18, 2019 17:30

MSD-AH
Telephone: 01908 685685 (Customer Support Centre)
Release 3.4
Panacur Granules 22.2 % w/w
 
Species: Cats, Dogs
Therapeutic indication: Pharmaceuticals: Endoparasiticides: Anthelmintics for dogs, Anthelmintics for cats
Active ingredient: Fenbendazole
Product:Panacur® granules 22.2% w/w
Product index: Panacur granules
Qualitative and quantitative composition
Active ingredient
Fenbendazole: 22.2 % w/w
 
For full list of excipients, see section “Pharmaceutical particulars”.
 
Pharmaceutical form
Granules.
White or yellowish-white granular powder.
Clinical particulars
Target species
Domestic dogs, cats, puppies and kittens.
Indications for use
For the treatment of domestic dogs and cats infected with immature and mature stages of nematodes of the gastro-intestinal and respiratory tracts.
 
Adult dogs and cats: For the treatment of adult dogs and cats infected with gastro-intestinal nematodes and cestodes:
Ascarid spp. (Toxocara canis, Toxocara cati, Toxascaris leonina)
Ancylostoma spp.
Trichuris spp.
Uncinaria spp.
Taenia spp.
 
Puppies and kittens: For the treatment of weaned puppies and kittens infected with gastro-intestinal nematodes and puppies infected with protozoa (Giardia spp):
 
Pregnant dogs: For the treatment of pregnant dogs to reduce prenatal infections with Toxocara canis and the transfer of T.canis and Ancylostoma caninum to their pups via the milk.
 
Also for the treatment of dogs infected with lungworm Oslerus (Filaroides) osleri or protozoa Giardia spp. and cats infected with lungworm Aelurostrongyles abstrusus
 
Panacur also has an ovicidal effect on nematode eggs.
Contra-indications
None.
Special warnings for each target species
None.
Special precautions for use
Special precautions for use in animals
Assess body weight as accurately as possible before calculating the dosage.
Operator warnings:
Direct contact with the skin should be kept to a minimum.
Avoid inhalation of granule dust. Wash hands after use.
Adverse reactions
Gastrointestinal signs (such as vomiting and diarrhoea) can occur in very rare cases in dogs and cats.
Use during pregnancy, lactation or lay
The product can also be safely administered to pregnant dogs and cats.
As teratogenic effects in dogs and cats cannot be completely ruled out in very rare cases, the treatment in the first two trimesters of pregnancy should be based on the benefit-risk evaluation by the responsible veterinarian.
Interactions
None known.
Amounts to be administered and administration route
Routine treatment of adult dogs and cats
Administer 100mg fenbenbazole per 1 kg (2.2 lb) body weight as a single dose.
Practical dosage recommendations:
1 g sachet /dose
Treats 2 kg (4.4lb) body weight as a single dose (1.1 – 2.2 kg)
1.8 g sachet / dose
Treats 4 kg (8.8lb) body weight as a single dose (2.2 – 4.4 kg)
4.5 g sachet /dose
Treats 10 kg (22lb) body weight as a single dose (5 – 10 kg)
For dogs weighing over 10 kg (22 lbs), additional sachets are required according to the additional body weight.
Assess body weight as accurately as possible and then administer one or a combination of the above sachets, which most closely doses this body weight. The dose should be administered by mixing into the feed.
e.g.
For a 9kg dog = 2 kg dose (1g sachet) + 4 kg dose (1.8g sachet) + 4 kg dose (1.8g sachet).
i.e.
one × 1 gram sachet + two × 1.8gm sachets (10 kg dose)
or
one × 4.5 gram sachet (10 kg dose)
Treatment should be repeated when natural re-infection with parasitic worms occurs. Routine treatment of adult animals with minimal exposure to infection is advisable 2 to 4 times per year. More frequent treatment, at 6 to 8 weekly intervals is advisable for dogs in kennels.
Weaned puppies and kittens under six months of age
Administer 50 mg fenbendazole per 1 kg (2.2 lbs) body weight daily for 3 consecutive days.
Practical dosage recommendations:
1 g sachet /dose
Treats 4kg (8.8 lb) body weight (minimum weight 2.2 kg) dosed daily for three consecutive days (2.2 – 4.4 kg)
1.8 g sachet / dose
Treats 8 kg (17.6 lb) body weight dosed daily for three consecutive days (4.5– 8 kg)
4.5 g sachet /dose
Treats 20 kg (44 lb) body weight dosed daily for three consecutive days (10– 20 kg)
For dogs/puppies weighing over 20 kg (44 lbs) additional sachets are required according to the additional body weight.
Assess body weight as accurately as possible and then administer one or a combination of the above sachets, which most closely doses this body weight. The dose should be administered by mixing into the feed.
N.B. Smaller or unweaned puppies and kittens should be treated with Panacur 2.5% or 10% Liquid or Panacur Paste.
e.g.
For a 9 kg dog = 4 kg dose (1g sachet) + 8 kg dose (1.8g sachet) daily for 3 consecutive days.
i.e.
one × 1 gram sachet + one × 1.8gm sachets. (12 kg) dose daily for 3 days
or
three × 1 gram sachet (12 kg dose) daily for 3 days
Puppies should be treated at 2 weeks of age, 5 weeks of age and again before leaving the breeder's premises. Treatment may also be required at 8 and 12 weeks of age. Thereafter, frequency of treatment can be reduced unless the pups remain in kennels where re-infestation occurs more readily.
Pregnant dogs
Administer 25mg fenbendazole per 1 kg (2.2 lb) body weight daily from day 40 of pregnancy continuously to 2 days post-whelping (approximately 25 days).
Practical dosage recommendations:
1 g sachet /dose
Treats 8 kg (17.6 lb) body weight dosed daily for approx. 25 days
1.8 g sachet / dose
Treats 16 kg (35.2 lb) bod yweight dosed daily for approx. 25 days
4.5 g sachet /dose
Treats 40 kg (88 lb) body weight dosed daily for approx. 25 days
For bitches weighing over 40 kg, additional sachets are required according to the additional body weight.
Pregnant cats
Pregnant cats can be safely treated with this product.
Increased dosing for specific infections
For the treatment of clinical worm infestations in adult dogs and cats or Giardia spp. infections in dogs, administer 50mg fenbendazole per 1kg (2.2 lb) body weight daily for 3 consecutive days.
For control of lungworm Oslerus (Filaroides) osleri in dogs administer 50mg fenbendazole per 1kg (2.2 lb) body weight, daily for 7 consecutive days. A repeated course of treatment may be required in some cases.
For the control of lungworm Aelurostrongylus abstrusus in cats administer 50mg fenbendazole per 1kg (2.2 lb) body weight daily for 3 consecutive days.
Overdose
Benzimidazoles have a high margin of safety. No specific overdose symptoms are known. No specific actions required.
Withdrawal periods
Not applicable.
Pharmacological particulars
Pharmacodynamic properties
ATC Vet Code: QP52 AC 13
Fenbendazole is an anthelmintic belonging to the benzimidazole carbamates group. It acts by interfering in the energy metabolism of the nematode. The anthelmintic efficacy is based on inhibition of the polymerisation of tubulin to microtubuli. The anthelmintic affects both adult and immature stages of gastro-intestinal and respiratory nematodes.
Pharmacokinetic properties
Fenbendazole is only partly absorbed from the intestine and reaches maximum plasma concentration in dogs 6 - 24 hours after oral administration. In cats the mean maximum serum concentration of fenbendazole was reached about 4 hours after treatment. Administration of fenbendazole in food did significantly increase its bioavailability compared to the administration on an empty stomach.
Fenbendazole is metabolised mainly by enzymes of the cytochrome P -450 system in the liver. The major oxidative metabolite is fenbendazole sulfoxide which is further metabolised to fenbendazole sulfone.
Fenbendazole and its metabolites are distributed throughout the body but highest concentrations are found in the liver.
The elimination half-life from plasma is about 15 hours after oral administration.
 
Fenbendazole and its metabolites are predominantly excreted via the faeces.
Pharmaceutical particulars
Excipients
Lactose monohydrate, Povidone 2500 and Maize starch.
Major incompatibilities
None known.
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 36 months.
Special precautions for storage
No special precautions for storage.
Immediate packaging
Pack sizes: 1g, 1.8g and 4.5g sachets.
Container: Low density polyethylene/aluminium foil/paper laminated sachet.
Not all pack sizes may be marketed.
Disposal
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Marketing Authorisation Number
Vm 01708/4427
Significant changes
Date of the first authorisation or date of renewal
23 January 1998.
Date of revision of the text
May 2016.
Any other information
For animal treatment only. Keep out of the sight and reach of children.
Legal category
Legal category: NFA-VPS
GTIN
GTIN description:Panacur Granules 22.2% 10x3x1.8g:
GTIN:05032984101140,
GTIN description:Panacur Granules 22.2% 10x3x4.5g:
GTIN:05032984101164,
GTIN description:Panacur Granules 22.2% 60x4.5g:
GTIN:05032984101195,
GTIN description:Panacur Granules 22.2% 90x1.8g:
GTIN:05032984101188