Do not vaccinate animals less than 3 weeks before mating.
Do not use during pregnancy.
A transient temperature rise is normally observed (up to 41 °C, returning to normal within 7-8 days of vaccination).
At 20 times dose no particular signs, other than a transient temperature increase similar to that seen with a single dose (although up to 41.5 - 42 °C) have been observed.
Safety and efficacy data are available which demonstrate that this vaccine can be administered on the same day but not mixed with Enzovax (Vm 01708/4523). It should be given at separate sites.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except Enzovax. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Do not mix with any other veterinary medicinal product except the diluent Unisolve supplied for use with the product.
Toxoplasma is only one of the causes of abortion in sheep. Where abortion occurs in sheep which have been vaccinated with Toxovax then it is recommended that veterinary advice is sought immediately to clarify the likely cause.
Care should be taken in handling such abortions as susceptible humans may be at risk of infection.
A good immune response is reliant on the reaction of an immunogenic agent and a fully competent immune system. Immunogenicity of the vaccine antigen will be reduced by poor storage or inappropriate administration. Immuno-competence of the animal may be compromised by a variety of factors including poor health, nutritional status, genetic factors, concurrent drug therapy and stress.
Only healthy animals should be vaccinated.
Toxovax should not be handled by pregnant women, or women of child-bearing age as the vaccine may interfere with normal foetal development.
Toxovax should not be handled by persons who are immunodeficient (e.g. AIDS sufferers; persons undergoing chemotherapy or taking immunosuppressive drugs).
Operators should wear gloves when handling the vaccine.
Living tachyzoites can cause disease in man.
Care should be taken to avoid self-injection and to avoid vaccine getting into the mouth or the eyes. In the case of self-injection, immediate medical advice should be sought and the doctor should be informed that self-injection with a living tachyzoite toxoplasma vaccine has occurred. Pyrimethamine therapy is the current recognised treatment for toxoplasmosis in humans.
Meat and offal: 42 days.
For animal treatment only. Keep out of the sight and reach of children.