Vaginal use. 1.38 g of progesterone (1 device) per animal for 7 - 9 days (depending on indication).
For synchronisation of oestrus and synchronisation of donor and recipient animals for embryo transfer:
One device should be inserted into the vagina of each cow or heifer to be treated. The vaginal insert should be left in position for 7 days with an injection of a luteolytic dose of prostaglandin F2α or analogue administered 24 hours prior to removal. In animals that respond to treatment the onset of oestrus generally occurs within 1-3 days after removal of the insert. Cows should be inseminated within 12 hours of first observed oestrus.
For the induction and synchronisation of oestrus for Fixed Time Artificial Insemination (FTAI):
The following FTAI protocols have been commonly reported in the scientific literature and should be used:
In cycling cows and heifers
- Insert one CIDR 1.38 g into vagina for 7 days.
- Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal.
- FTAI 56 hours after removal of the device.
In cycling and non-cycling cows and heifers
- Insert one CIDR 1.38 g into vagina for 7- 8 days.
- Inject a dose of GnRH or analogue at CIDR 1.38g insertion.
- Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal.
- FTAI 56 hours after removal of the device, or
- Inject GnRH or analogue 36 hours after CIDR 1.38 g removal and FTAI 16 to 20 hours later.
In non-cycling cows
The following FTAI protocol should be used:
- Insert one CIDR 1.38 g into vagina for 9 days.
- Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal.
- Inject eCG at CIDR 1.38 g removal.
- FTAI 56 hours after removal of the device, or inseminate within 12 hours following first observed oestrus behaviour.
Administration:
A device applicator should be used for administration, following the procedure described below:
1Ensure that the applicator is clean and dipped in a non-irritant antiseptic solution before use.
2Wearing sterile disposable plastic gloves, fold the arms of the device and load into the applicator. The arms of the device should protrude slightly from the end of the applicator. Care should be taken to avoid unnecessary or prolonged handling of the product to minimise transfer of the active substance to the operator's gloves.
3Apply a small quantity of obstetrical lubricant to the end of the loaded applicator.
4Lift the tail and clean the vulva and perineum.
5Gently insert the applicator into the vagina, first in a vertical direction and then horizontally until some resistance is encountered.
6Make sure the removal string is free, press the handle of the applicator and allow the barrel to move back towards the handle. This releases the arms of the device, which will then retain the device in the anterior vagina.
7With the device correctly positioned, withdraw the applicator, leaving the removal string hanging from the vulva.
8The applicator should be cleaned and disinfected before being used on another animal.
Removal:
The device may be removed by gently pulling on the string. On occasions the string may not be visible from the outside of the animal, in such cases it may be located in the posterior vagina using a gloved finger. Withdrawal of the device should not require force. If any resistance is encountered a gloved hand should be used to ease removal.
If there is any difficulty in removal from the animal beyond that itemised above veterinary advice must be sought.
The device is intended for single use only.