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Date: Friday, March 29, 2024 8:51

Description: Zoetis logo
Release 3.146
Rispoval 4
 
Species: Cattle
Therapeutic indication: Immunological veterinary medical products: For cattle
Active ingredient: Vaccine Antigens
Product:Rispoval® 4
Product index: Rispoval 4
Cattle - milk: Zero days
Cattle - meat: Zero days
Incorporating:
Presentation
An off-white freeze-dried pellet containing attenuated strains of BRSV (Bovine Respiratory Syncytial Virus) and PI3 (Parainfluenza type 3) viruses supplied together with a suspension containing inactivated, adjuvanted IBR (Infectious Bovine Rhinotracheitis – BHV-1) and BVD (Bovine Viral Diarrhoea) cytopathic and non-cytopathic Type 1 viruses.
Uses
For active immunisation of cattle to reduce infection, clinical signs and respiratory disease caused by Bovine Respiratory Synctial Virus (BRSV), Infectious Bovine Rhinotracheitis (IBR, caused by BHV-1) virus and Parainfluenza type 3 Virus (PI3); and leucopenia and viraemia caused by the Bovine Viral Diarrhoea (BVD) virus Type 1 cytopathic and non-cytopathic strains. A duration of immunity of at least 6 months has been demonstrated.
Dosage and administration
Reconstitute the vaccine by adding the liquid fraction to the freeze dried vial containing the lyophilised plug.
When the lyophilised plug and liquid fraction are in equally sized vials:
Inject the entire liquid fraction into the freeze dried vial.
When the lyophilised plug is in a smaller sized vial than the liquid fraction, the reconstitution of the vaccine is carried out in 2 steps:
Inject 10ml of the liquid fraction on the lyophilised plug in the freeze dried vial.
Shake well and extract the part reconstituted vaccine from the freeze dried vial and mix with the remaining liquid in the liquid fraction vial.
Shake well before use.
Vaccination programme
For cattle over 3 months of age
Two doses of 5ml of reconstituted vaccine should be given three to four weeks apart to cattle over the age of 3 months, via the intramuscular route.
Ideally, calves should be vaccinated at least 2 weeks before transport, mixing of animals of different origins, housing or any other event which may cause the animals to be stressed or exposed to new infections. Calves are usually most susceptible during early autumn. The vaccine will protect animals against BRSV, PI3, IBR and BVD for at least 6 months, which will cover the period of risk from respiratory infections.
Should cattle be at risk from these respiratory diseases at a subsequent time, the same vaccination scheme is recommended at least 14 days prior to the period of expected disease challenge.
For cattle over 3 weeks of age
For cattle from 3 weeks of age, vaccination leads to seroconversion of seronegative calves vaccinated at 3 and 6 weeks of age. The influence of maternally derived antibodies has not been studied in detail and it is therefore recommended that calves vaccinated before 12 weeks of age are re-vaccinated at 12 weeks of age.
Contra-indications, warnings, etc
Do not vaccinate pregnant animals.
Very rarely, administration of the vaccine may be followed by a mild transient reaction at the injection site up to 0.5cm and completely resolved within 15 days.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Safety and efficacy data are available which demonstrate that this vaccine can be used on the same day but not mixed with Rispoval Pasteurella.
No information is available on the safety and efficacy of this vaccine when used with any other veterinary medicinal product except the product mentioned above. A decision to use this vaccine before or after any other veterinary medicinal product therefore needs to be made on a case by case basis.
Do not mix with any other veterinary medicinal product, except the solvent supplied for use with the veterinary medicinal product.
Withdrawal Period
Zero days.
Pharmaceutical precautions
Store and transport refrigerated (2° - 8°C). Do not freeze. Protect from light.
Shelf life after reconstitution: 2 hours.
For animal treatment only.
Keep out of the sight and reach of children.
Legal category
Legal category: POM-V
Packaging quantities
Vials containing 5 doses of freeze-dried component are available, together with an equal number of vials of suspension in 5 doses (25ml).
Disposal
Any unused veterinary medicinal product or waste material derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Marketing Authorisation Number
Vm 42058/4125
Significant changes
GTIN
GTIN description:5 dose:
GTIN:05013457078824