An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes. Administration by intramuscular (IM), intravenous (IV) and subcutaneous (SC) routes are possible. The effect is most rapid after IV administration and slowest after SC administration. The dosage is dependent on the degree of sedation and analgesia required.
Domitor | Dose mcg/kg |
Dogs | 10-80 |
Cats | 50-150 |
| |
For sedation, small dogs require more Domitor per kg of bodyweight than large dogs thus the dosage per square metre of body surface could be more accurate. If this approach is used the dosage is 750 to 1000 mcg/square metre.
The following table gives the dosage for dogs on the basis of body weight.
Body weight (kg) IV administration | Injection volume (ml) | Body weight (kg) IM/ SC/ administration |
1.5-2.2 | 0.1 | |
2.3-3.5 | 0.15 | 1.8-2.3 |
3.6-5.1 | 0.2 | 2.4-3.3 |
5.2-6.9 | 0.25 | 3.4-4.5 |
7.0-9.9 | 0.3 | 4.6-6.4 |
10.0-14.4 | 0.4 | 6.5-9.4 |
14.5-19.5 | 0.5 | 9.5-12.7 |
19.6-25.1 | 0.6 | 12.8-16.3 |
25.2-31.1 | 0.7 | 16.4-20.2 |
31.2-37.6 | 0.8 | 20.3-24.4 |
37.7-44.4 | 0.9 | 24.5-28.9 |
44.5-55.3 | 1.0 | 29.0-36.1 |
55.4-71.1 | 1.2 | 36.2-46.3 |
71.2-88.2 | 1.4 | 46.4-57.3 |
88.3 + | 1.6 | 57.4-75.8 |
| 2.0 | 75.9 + |
| | |
Anesthesia: Domitor is suitable for use as an anesthetic premedication prior to general anesthesia. Premedication dosing guide: Medetomidine has marked anaesthetic-sparing effects. It is essential to reduce appropriately the dose of anaesthetic induction and maintenance agents in animals that have been given the product.
Combinant | Dosage (Dogs) | | Dosage (Cats | |
| Domitor (mcg/kg) | Combinant (mg/kg) | Domitor (mcg/kg) | Combinant mg/kg) |
Propofol | 10-40 | 1-4 | NA | NA |
Butorphanol | 10-25 | 0.1 | 50 | 0.4 |
Ketamine | | | 80 | 2.5-7.5 |
Butorphanol + Ketamine | NA | NA | 40-80 | But: 0.1-0.4 Ket: 1.25-5.0 |
Alfaxalone /alfadolone | NA | NA | 80 | 2.5-5.0 |