PHARMACOLOGICAL PROPERTIES
ATC Vet Code: J01CA04
Pharmacotherapeutic group: Antiinfectives for systemic use
Pharmacodynamic properties: Stabox contains 5% coated amoxicillin for oral administration to piglets as a medicated-feed supplement. The formulation of Stabox is based on a new concept of coating the active ingredient. This method stabilises the amoxicillin and makes it less sensitive to temperature variations during storage, pelleting and storage of pelleted feed. Amoxicillin is a bactericidal antibiotic of the beta-lactam family which acts by blocking the biosynthesis of the cell wall. As a bactericidal antibiotic, amoxicillin inhibits the development of the peptidoglycan network structure of the bacterial cell wall. It is thought to act on transpeptidation which is the last step in the synthesis of the final bacterial membrane structure. Amoxicillin exerts very low M.I.C. values against Streptococcus suis type 2 (MIC 90 < 0.02 µg/ml) and is very active against other Streptococcus micro-organisms, Corynebacteria (Actinomyces, Eubacteria) Clostridia, Bacillus anthracis for the gram-positive bacteria and Pasteurella, Escherichia coli, Salmonella, Bordetella for the gram-negative bacteria.
Pharmacokinetic properties: When administered orally to 7-week-old piglets at the recommended dosage of 15 mg/kg bodyweight/day for 14 days, therapeutic plasma levels were maintained throughout the treatment. Amoxicillin is mainly excreted in the urine under its natural form and as penicilloic acid.