Effipro Duo for small dogs: dogs (2-10 kg)

Effipro Duo for medium dogs: dogs (10-20 kg)

Effipro Duo for large dogs: dogs (20-40 kg)

Effipro Duo for very large dogs: dogs (40-60 kg)

To be used against infestations with fleas alone or in association with ticks.

Treatment and prevention of infestations by fleas (Ctenocephalides felis). One treatment prevents further infestations for 7 weeks.

Prevention of the multiplication of fleas by preventing flea eggs developing into adult fleas for 12 weeks after application.

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD) where this has been previously diagnosed by a veterinary surgeon.

Treatment of infestations by ticks (Ixodes ricinus).

One treatment provides persistent acaricidal efficacy for 2 weeks against Ixodes ricinus, and for 4 weeks against Dermacentor reticulatus and Rhipicephalus sanguineus.

If ticks of some species (Dermacentor reticulatus, Rhipicephalus sanguineus) are present at the time of application, not all ticks may be killed within 48 hours.

Do not use in rabbits, as adverse reactions and even death could occur.

Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.

Shampooing or immersion of the animal in water directly after treatment may reduce the duration of activity. The product remains effective against fleas for 5 weeks when the dog is shampooed at monthly intervals after treatment. If the dog requires shampooing, it is better to do so before treatment.

Water immersion repeated on two occasions post treatment did not affect adulticidal efficacy against fleas nor the efficacy related to the prevention of the development of flea eggs into adult fleas.

The influence of water immersion or shampooing of the dog on the efficacy of the product against ticks has not been evaluated.

At the beginning of the control measures, in the case of an infestation, the animal's basket, bedding and regular resting areas such as carpets and soft furnishings should be treated, with a suitable insecticide and vacuumed regularly.

To reduce environmental flea challenge, all animals living in the same household should also be treated with a suitable flea control product.

The product does not prevent ticks from attaching to animals. Transmission of infectious disease by ticks cannot be completely excluded if conditions are unfavourable.

Immediate efficacy has been demonstrated against Ixodes ricinus, indicating that ticks of this species are likely to be killed within 48 hours of product application. If Dermacentor reticulatus or Rhipicephalus sanguineus ticks are present when the product is applied, these ticks may not be killed within the first 48 hours.

Once dead, ticks will often drop off the animal. Any remaining ticks should be carefully removed, ensuring that their mouth parts are not left within the skin.

For external use only.

Animals should be weighed accurately prior to treatment.

In absence of safety data, the product should not be used in puppies less than 10 weeks old and/or weighing less than 2 kg.

Care should be taken to avoid the content of the pipette coming into contact with the eyes or mouth of the recipient dogs. In particular oral uptake due to the licking of the application site by treated or in-contact animals should be avoided.

Do not apply the product on wounds or damaged skin.

In the absence of additional safety studies, do not repeat the treatment at intervals of less than 4 weeks.

The use of the product has not been studied in sick and debilitated dogs.

Consult your veterinary surgeon before using the product if your dog is unwell or currently receiving any other veterinary treatment.

Inform your veterinary surgeon that you are using this product if s/he provides your dog with any other medication.

Seek veterinary advice if the product is accidentally ingested or comes into contact with your animal’s eyes.

The product may cause neurotoxicity.

The product may be harmful if swallowed.

Avoid contact with skin and mouth.

Do not smoke, drink or eat during application.

In the event of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.

This product can cause eye and mucous membrane irritation.

Avoid contact with skin, eye and mouth, including hand to eye contact.

In the case of accidental skin or eye contact, immediately and thoroughly flush with water.

If skin or eye irritation persists, seek medical advice and show the package leaflet or the label to the physician.

Wash hands after use.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals should not be allowed to sleep with owners, especially children.

Keep the pipettes in the original packaging until ready for use and dispose of used pipettes immediately.

Fipronil and pyriproxyfen may adversely affect aquatic organisms. Dogs should be prevented from accessing streams and rivers for 48-hours following treatment.

The product may have adverse effects on painted, varnished or other household surfaces or furnishings. Allow the application site to dry before permitting contact with such materials.

Transient cosmetic effects such as wet appearance or slight scaling can occur very rarely at the application site.

According to the accumulated experience on these active ingredients within spot on pharmaceutical forms, transient cutaneous reactions at the application site as squamosis (scaling of the skin), local alopecia (hair loss), pruritus (itchiness), erythema(redness of the skin), skin discolouration and general pruritus or alopecia may very rarely be observed after use. Hypersalivation, reversible neurologic symptoms as hyperesthesia (increased sensitivity to stimuli), depression and nervous symptoms may very rarely be observed.

Respiratory signs or vomiting might occur in very rare cases.

Laboratory studies using fipronil and pyriproxyfen have not shown any evidence of teratogenic or embryotoxic effect. The safety of the product has not been established in pregnant and lactating bitches. Consult your veterinary surgeon before using the product in pregnant or lactating bitches.

Do not use simultaneously with other flea or tick products which are applied directly on to the animal

Spot-on use.

Apply one pipette of appropriate volume per dog as per the table below, corresponding to the minimal recommended dose of 6.7 mg fipronil /kg b.w. and 2 mg pyriproxyfen/kg b.w.

For dogs over 60 kg the appropriate combination of pipettes should be used.

Remove the pipette from the overblister. Hold the pipette upright. Tap the narrow part of the pipette to ensure that the contents are within the main body of the pipette. Break the snap-off top of the spot-on pipette along the scored line.

Part the pet’s coat on base of the neck before the shoulder blades until the skin is visible. Place the tip of the pipette directly against the skin and squeeze gently several times to empty the contents. If necessary the contents of the pipette can be administered at one or two additional point(s) along the pet’s back to avoid run-off or more superficial application to the hair coat, particularly in large dogs.

Pipettes have a drop stop system (the product is released only by pressing the body of the pipette).

One pipette provides a single treatment, with the possibility to repeat administrations on a monthly basis.

Consult your veterinary surgeon if the product fails to control the flea and tick infestation.

No serious adverse effects were observed in a safety study in 10-week old puppies treated with up to 5 times the maximum recommended dose 3 times at intervals of 4 weeks and with the maximum recommended dose 6 times at intervals of 4 weeks.

The risk of experiencing adverse reactions may however increase with overdosing, so animals should always be treated with correct pipette size according to bodyweight.

Not applicable