Pharmacotherapeutic group:
Antifungals for dermatological use, other antifungals for topical use.
ATCvet Code: QD01AE91
Pharmacodynamic properties
Mechanism of action:
The mode of action of bronopol was considered to result from blocking thiol containing enzymes such as membrane bound dehydrogenase, causing alterations to the cell membrane, leading to cell leakage and destruction.
The efficacy of bronopol against Saprolegnia spp was dose-dependent.
Resistance or a high level of tolerance in micro-organism has not been reported with use of bronopol.
Pharmacokinetic particulars
Studies conducted in Atlantic salmon with radiolabelled bronopol and residue analysis of rainbow trout treated for 14 days with the product at the recommended dose indicate that bronopol is not absorbed to an appreciable extent when used as a topical treatment.