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Clinical particulars
Target species
Cats.
Indications for use
To be used against infestations with fleas, alone or in association with ticks and/or biting lice.
- Treatment of fleas (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for 6 weeks after application.
- Treatment of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks against ticks (based on experimental data).
- Treatment of biting lice (Felicola subrostratus).
Contraindications
In the absence of available data, the product should not be used on kittens less than 8 weeks old and/or weighing less than 1kg. Do not use on sick (e.g. systemic diseases, fever) or convalescent animals. Do not use if your cat has a hypersensitivity to fipronil or S-methoprene or the other ingredients. Do not use in rabbits, as adverse drug reactions with even mortality could occur. Do not use in any other non‑target species.
Special warnings for each target species
When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time. Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly. Bathing and/or shampooing should be avoided. No information on the effect of bathing or the use of a shampoo on the effectiveness of the product in cats is available. Based on information available for dogs, bathing/immersion in water within 2 days after application of the product and more frequent bathing than once a week should be avoided. It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.
Special precautions to be taken by the person administering the veterinary medicinal product
This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided. People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid contact with the product. Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water. After accidental ocular exposure the eye should be rinsed carefully in clean water. If the product is accidentally swallowed, seek medical advice immediately and show the package leaflet to the physician. Wash hands after use. Do not smoke, drink or eat during application. Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children. Keep pipettes in original packaging until ready to use.
Other precautions
The product may have adverse effects on painted, varnished or other household surfaces or furnishings.
Adverse reactions
Among the very rare suspected adverse reactions, transient skin reactions on the application site (scaling, local hair loss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs) or vomiting have also been observed after use. In the case of licking the administration site, a brief period of excessive salivation may be observed due mainly to the nature of the carrier. The risk of adverse effects may increase in cases of overdose.
Use during pregnancy and lactation
The product can be used during pregnancy. The potential toxicity of the product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case.
Interaction with other medicinal products
Do not use simultaneously with other flea products which are applied directly on to the animal.
Dosage and administration
One pipette of 0.5ml per cat, corresponding to a minimum recommended dose of 5mg/kg for fipronil and 6mg/kg for S-methoprene, by topical application to the skin. In the absence of safety studies, the minimum treatment interval is 4 weeks.
Remove the pipette from its packaging. Hold the pipette in an upright position, twist and pull the cap off. Turn the cap around and place the other end of the cap back on the pipette. Push and twist the cap to break the seal, then remove the cap from the pipette. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette onto the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.
Overdose
The risk of experiencing adverse effects may increase with overdosing. No undesirable effects were observed in target animal safety studies in cats and kittens aged 8 weeks and older and weighing about 1kg treated once a month at five times the recommended dose for six consecutive months. Itching may occur following treatment. Overdose application of the product will cause a sticky appearance of hairs at the treatment spot. However, should this occur, it will disappear within 24 hours post application.