For active immunisation of clinically healthy pigs from 1 day of age in a porcine reproductive and respiratory syndrome (PRRS) virus contaminated environment, to reduce viraemia and nasal shedding caused by infection with European strains of PRRS virus (genotype 1).
Onset of immunity: 21 days after vaccination.
Duration of immunity: 26 weeks after vaccination.
Fattening pigs
In addition, intramuscular vaccination of seronegative 1-day-old piglets was demonstrated to reduce lung lesions against challenge administered at 26 weeks post vaccination. Intramuscular vaccination of seronegative 2-week-old piglets was demonstrated to reduce lung lesions and oral shedding against challenge administered at 28 days and at 16 weeks post-vaccination.
Additionally, nasal vaccination of seronegative 3-day-old piglets reduced viraemia, nasal shedding and lung lesions against challenge administered at 21 days post-vaccination. Nasal vaccination of seropositive 3-day-old piglets reduced viraemia, nasal shedding and lung lesions against challenge administered 10 weeks post-vaccination.
Gilts and sows
In addition, pre-pregnancy vaccination of clinically healthy gilts and sows, non-PRRS virus-naïve (i.e. either previously immunised against PRRS virus via vaccination or exposed to PRRS virus via field infection) or PRRS virus-naïve, was demonstrated to reduce the transplacental infection caused by PRRS virus during the last third of pregnancy, and to reduce the associated negative impact on reproductive performance (reduction of the occurrence of stillbirths, of piglet viraemia at birth and at weaning, of lung lesions and of viral load in lungs in piglets at weaning).