Anthelmintics, benzimidazole derivatives – fenbendazole.
ATCvet Code: QP52AC13
Pharmacodynamic properties
Fenbendazole is an anthelmintic belonging to the benzimidazole-carbamate group. It acts by interfering with the energy metabolism of the nematode.
Fenbendazole inhibits the polymerisation of tubulin to microtubules. This interferes with essential structural and functional properties of the cells of helminths, such as formation of the cytoskeleton, formation of the mitotic spindle and the uptake and intracellular transport nutrients and metabolic products. Fenbendazole is active and has a dose dependent activity on the adult-, intestinal and migratory stages of Ascaris suum.
Pharmacokinetic particulars
After oral administration fenbendazole is only partially absorbed. Following absorption, fenbendazole is rapidly metabolised in the liver mainly to its sulphoxide (oxfendazole) and further to its sulphone (oxfendazole sulphone). In pigs oxfendazole is the main component detected in plasma, accounting for about 2/3 of the total AUC (i.e. the sum of the AUC for fenbendazole, oxfendazole and oxfendazole sulphone. Fenbendazole and its metabolites are distributed throughout the body, reaching highest concentrations in the liver. The elimination of fenbendazole and its metabolites occurs primarily via the faeces and to a small extent in the urine.
Pharmaceutical Particulars
List of excipients
Sodium benzoate (E211)
Docusate sodium
Povidone
Hydrochloric acid, concentrated (for pH adjustment)
Water for injections
Major incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.