Target species
Cattle, Sheep, Pigs
Indications for use, specifying the target species
For the treatment of conditions caused by or associated with organisms sensitive to oxytetracycline including:
•Bordetella bronchiseptica
•Actinomyces pyogenes
•Erysipelothrix rhusiopathiae
•Pasteurella spp
•Staphylococcus spp
•Streptococcus spp
Certain mycoplasma, rickettsiae, protozoa and chlamydia are also sensitive to oxytetracycline.
The product is indicated for the treatment and control of pasteurellosis, pneumonia, atrophic rhinitis, erysipelas, joint-ill, navel-ill, summer mastitis in cows, ovine keratoconjunctivitis (pink-eye) and enzootic abortion in sheep.
Contraindications
Do not dilute the product.
Special Warnings for each target species
Oxytetracycline therapy does not completely eliminate chlamydial infection in the flock.
Special precautions for use
Special precautions for use in animals
If concurrent treatment is administered, use a separate injection site. Resistance against oxytetracycline may vary.
Use of the product should be based on susceptibility testing of bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information about susceptibility of the target bacteria.
Inappropriate use of the product may increase the prevalence of bacteria resistant to oxytetracycline and may decrease the effectiveness of treatment with tetracyclines due to the potential for cross resistance.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
This product may cause hypersensitivity reactions (allergy). Persons with a known hypersensitivity to tetracyclines should not handle this product. Wash hands after use. In case of contact with eyes or skin, wash off immediately with water as irritation may occur. Avoid accidental self-injection.
Adverse reactions (frequency and seriousness)
Although the product is well tolerated, occasionally a slight local reaction of a transient nature may be observed. Collapse has been reported with tetracyclines in weak or debilitated animals.
Other adverse reactions to oxytetracycline that have been observed include gastrointestinal disorders and, less frequently, allergic and photosensitivity reactions.
In very rare cases, hypersensitivity, allergic or anaphylactic type reactions may occur. If such reactions occur, appropriate treatment is recommended
The frequency of adverse reactions is defined using the following convention:
•very common (more than 1 in 10 animals treated displaying adverse reaction(s))
•common (more than 1 but less than 10 animals in 100 animals treated)
•uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
•rare (more than 1 but less than 10 animals in 10,000 animals treated)
•very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Use during pregnancy, lactation or lay
The use of this product during the period of tooth and bone development, including late pregnancy, may lead to discoloration. The product can be safely administered during lactation.
Interaction with other medicinal products and other forms of interaction
Oxytetracycline may interfere with the action of bactericidal antimicrobials, such as penicillins and cephalosporins, and therefore they should not be used simultaneously.
Concomitant vaccination is not recommended because of possible immunosuppressive activity of tetracyclines.
Amounts to be administered and administration route
To ensure a correct dosage, bodyweight should be determined as accurately as possible, to avoid under dosing.
Deep intramuscular injection.
Alamycin LA 300 can be administered at the standard dose of 20 mg/kg to obtain 3 to 4 days duration of activity or at a high dose of 30 mg/kg for prolonged duration of activity (i.e. activity maintained for 5 to 6 days).
Cattle, Sheep and Pigs:
•Standard dose - 20 mg/kg (1ml/15kg)
• High dose - 30 mg/kg (1ml/10kg)
Maximum recommended dosage at one site:
Cattle: - 15 ml
Pigs: - 10 ml
Sheep: - 5 ml
Piglets:
•1 day: 0.2ml
•7 days: 0.3 ml
•14 days: 0.4 ml
•21 days: 0.5 ml
•Over 21 days: 1ml/10 kg
This product does not contain an antimicrobial preservative. Swab the septum before removing each dose. Use a sterile needle and syringe.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Excessive dosages can cause nephrotoxicity in cattle. No treatment specified.
Withdrawal period
20 mg/kg dose:
Cattle – Meat & offal 28 days
Pigs – Meat & offal 14 days
Sheep – Meat & offal 28 days
30 mg/kg dose:
Cattle – Meat & offal 35 days
Pigs – Meat & offal 28 days
Sheep – Meat & offal 28 days
Cattle – Milk 8 days
Sheep – Milk 8 days.