Target species
Cattle and Dogs.
Indications for use, specifying the target species
Noroclav Injection has a broad-spectrum of bactericidal activity against the bacteria commonly found in cattle and dogs.
(a) In vitro Noroclav Injection is active against a wide range of clinically important bacteria including:
Gram-positive: Staphylococci (including beta-lactamase producing strains), Streptococci, Corynebacteria, Clostridia, Bacillus anthracis, Actinomyces bovis.
Gram-negative: Escherichia coli (including beta-lactamase producing strains), Salmonella spp (including beta-lactamase producing strains), Campylobacter spp, Klebsiella spp, Proteus spp, Pasteurellae spp, Fusobacterium necrophorum, Bacteroides (including beta-lactamase producing strains), Haemophilus spp, Moraxella spp and Actinobacillus lignieresi.
(b) Noroclav Injection is indicated for the treatment of diseases including:
Cattle:
•Respiratory infections
•Soft tissue infections (e.g. joint/navel ill, abscesses etc.)
•Metritis
•Mastitis.
Dogs:
•Respiratory tract infections
•Urinary tract infections
•Skin and soft tissue infections (e.g. abscesses, pyoderma, anal sacculitis and gingivitis.)
Contraindications
The product should not be administered to rabbits, guinea pigs, hamsters or gerbils. Caution is advised in its use in other very small herbivores.
Special Warnings for each target species
None.
Special precautions for use
Special precautions for use in animals
Do not use in animals with known hypersensitivity to penicillin or other substances of the beta-lactam group.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.
Handle this product with great care to avoid exposure, taking all recommended precautions.
If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.
Wash hands after use.
Adverse reactions (frequency and seriousness)
Use of the product may occasionally result in pain on injection and/or local tissue reaction.
Use during pregnancy, lactation or lay
The product may be used safely in pregnant animals.
Interaction with other medicinal products and other forms of interaction
None known.
Amounts to be administered and administration route
The product is indicated for intramuscular administration to cattle and subcutaneous administration to dogs.
The recommended dosage rate is 8.75 mg/kg bodyweight (1 ml per 20 kg bodyweight) daily for 3-5 days. Shake the vial well before use. After injection, massage the injection site. This product does not contain an antimicrobial preservative. Use a completely dry sterile needle and syringe. Swab the septum before removing each dose.
Care should be taken to avoid contaminating the remaining contents of a vial with water. Clavulanic acid is moisture sensitive. It is very important therefore, that a completely dry needle and syringe is used when extracting suspension for injection in order to avoid contaminating the remaining contents of the vial with drops of water. Contamination will result in obvious beads of dark, brown discolouration corresponding to the introduced water droplets. Material affected in this way should not be used as it may have significantly reduced potency.
Overdose (symptoms, emergency procedures, antidotes), if necessary
Potentiated penicillin is of a low order of toxicity and is well tolerated by the parenteral route. Apart from occasional injection site reactions, which may occur at the recommended dose, no other adverse effects are to be expected from an accidental overdose.
Withdrawal period
Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 42 days from the last treatment.
Milk for human consumption must not be taken during treatment. Milk for human consumption may be taken from treated cattle only after 80 hours from the last treatment.