Pharmacotherapeutic group: Antibacterials for systemic use, other antibacterials, pleuromutilins. ATCvet code: QJ01XQ01
Pharmacodynamic properties
Tiamulin hydrogen fumarate is a semi-synthetic diterpene antibiotic. The mode of action is by inhibition of ribosomal protein synthesis in sensitive bacteria. It is a bacteriostatic antimicrobial and the following organisms show sensitivity in-vitro:
Brachyspira: Brachyspira hyodysenteriae, B. pilosicoli.
Mycoplasmas: Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, Ureaplasma spp.
Gram-positive: Staphylococcus spp., Streptococcus spp., Arcanobacterium pyogenes.
Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus) spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli, Lawsonia intracellularis.
Pharmacokinetic particulars
Tiamulin is rapidly absorbed after oral administration. It concentrates in some tissues e.g. lungs and is rapidly metabolised and excreted.