Pharmacotherapeutic group: ß-lactam-antibiotic, Penicillins with extended spectrum.
ATCvet code: QJ01CA04
Pharmacodynamic properties
The active ingredient, amoxicillin, is a bactericidal, mainly time-dependant antibiotic of the beta-lactam class. It acts by inhibition of bacterial cell wall synthesis. Amoxicillin has a bactericidal effect on a wide range of Gram-positive and Gram-negative bacteria.
The MIC50/MIC90 of Actinobacillus pleuropneumoniae is 0.25 μg/ml. The MIC50/MIC90 of Streptococcus suis is ≤ 0.03 μg/ml.
In general, practical development of resistance in vitro against amoxicillin like all penicillins occurs slowly and stepwise, with an existing cross-resistance with other penicillins which is of practical significance in staphylococcus infections. Both long term treatment and sub-therapeutic dosages can select for antimicrobial resistance. Resistance to β-lactam antibiotics is essentially linked to β-lactamases which hydrolyse them.
Pharmacokinetic properties
With this veterinary medicinal product high amoxicillin concentrations are quickly reached in the blood. After oral administration, amoxicillin is largely absorbed (74-92%).
This antibiotic is well distributed to all organs and tissues, where also high concentrations are reached. Amoxicillin is largely excreted by the kidneys in the unchanged form. A smaller part of the administered dose of amoxicillin is excreted in the bile and also in the milk.