In cats following a single intravenous dose of alfaxalone at 5 mg/kg bw, the mean plasma elimination half-life (t1/2) is approximately 45 minutes. Plasma clearance is 25 ml/kg/min. Volume of distribution is 1.8 L/kg.
In dogs following a single intravenous dose of alfaxalone at 2 mg/kg bw, the mean plasma elimination half-life (t1/2) is approximately 25 minutes. Plasma clearance is 59 ml/kg/min. Volume of distribution is 2.4 L/kg.
In rabbits following a single intravenous dose of alfaxalone at 5 mg/kg bw, the mean plasma elimination half-life (t1/2) is approximately 46 minutes. Plasma clearance is 56 ml/kg/min. Volume of distribution is 3.6 L/kg.
In dogs, cats and rabbits the elimination of alfaxalone demonstrates non-linear (dose-dependent) pharmacokinetics.