Do not administer in case of severe liver and kidney disorder.

Do not administer in case of gastrointestinal ulcerations and chronic gastrointestinal disorders.

Do not administer in case of malfunction of the hematopoetic system, coagulopathy, haemorrhagic disease.

Use is not recommended during pregnancy and lactation because laboratory studies in rats have shown evidence of teratogenic and foetotoxic effects. Salicylic acid crosses the placenta and is excreted with the milk. Half-life in the new-born is longer and thus toxicity symptoms may occur much sooner. Furthermore platelet aggregation is inhibited and bleeding time increased, a situation which is not favourable during hard delivery/caesarean section. Finally some studies indicate that delivery is postponed.

Adverse reactions: Gastrointestinal irritation may occur especially in animals with pre-existing gastrointestinal disease. Such irritation may clinically be manifested by production of black manure due to blood loss in the gastrointestinal tract. Inhibition of normal blood clotting may occur incidentally. If this effect occurs it will be reversible and effects will diminish within approximately 7 days.

Interaction with other medicinal products and other forms of interaction: concurrent administration of potentially nephrotoxic drugs (e.g. aminoglycosides)) should be avoided. Salicylic acid is highly plasma bound and competes with a variety of compounds for plasma protein binding sites. Plasma clearance of SA had been reported to increase in combination with corticosteroids possible due to induction of metabolism of salicylic acid. Concurrent use with other NSAIDs is not recommended, because of increased risk of gastro-intestinal ulcers. Drugs which effect blood clotting should not be used in combination with sodium salicylate.

Special warning for each target species: non known.Special precautions for use: do not administer to neonates or to very young calves less than 2 weeks of age and piglets less than 4 weeks of age. Given that sodium salicylate may inhibit clotting of blood, it is recommended that elective surgery should not be performed on animals within 7 days after the end of treatment.Special precautions to be taken by the person administering the product to animals:People with known hypersensitivity to sodium salicylate or correlated pharmaceuticals should avoid contact with the veterinary medicinal product. Irritation of the skin, eye and respiratory tract might occur.During preparation and mixing of the product, direct contact with the skin and eyes, and direct inhalation of the powder should be avoided. It is recommended to wear gloves, safety glasses and a dust mask. Wash accidental exposure to skin immediately with water. During administration of the medicine ad reconstituted product in drinking water or milk (replacer) to the animals skin contact should be prevented by wearing gloves. Wash accidentally exposed skin immediately with water.

Pigs: meat and offal: zero days

Calves: meat and offal: zero days

Do not use in cows producing milk for human consumption.