Do not use in: young, growing cats, because of the possibility of the development of cartilage lesions. (cats aged less than 3 months or weighing less than 1kg). In the case that there is resistance to quinolones, as there exists almost complete cross resistance to other quinolones and complete cross resistance to other fluoquinolones. In cats having seizure disorders, since enrofloxacin may cause CNS stimulation. With tetracyclines, phenicols or macrolides because of potential antagonistic effects.

Retinotoxic effects including blindness can occur in cats when the recommended dose is exceeded. In laboratory studies, ocular adverse effects have been observed from 20 mg/kg.

Use the product with caution in cats with severe renal or hepatic impairment.

Vomiting or diarrhoea may appear during the treatment. These signs regress spontaneously and generally do not require treatment discontinuation.

Overdosing can cause vomiting and nervous signs (muscle tremor, incoordination and convulsions) which may require treatment discontinuation. In the absence of any known antidote, apply drug elimination and symptomatic treatment. If necessary, administration of aluminium or magnesium containing antacids or activated carbon can be used to reduce absorption of enrofloxacin.

Concurrent use of flunixin should be under careful veterinary monitoring, as the interactions between these drugs may lead to adverse events related to delayed elimination. Concomitant administration of theophylline requires careful monitoring as serum levels of theophylline may increase. Concurrent use of magnesium or aluminium containing substances (such as antacids or sucralfate) may reduce absorption of enrofloxacin. These drugs should be administered two hours apart.

Use during pregnancy: Studies in laboratory animals (rat, chinchilla) have not produced any evidence of a teratogenic, foetotoxic, maternototoxic effect. Use only according to the benefit/risk assessment by the responsible veterinarian. As enrofloxacin passes into the maternal milk, the use is not recommended during lactation.