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Advantage:  Dosage and administration
 
 
Advantage
Advantage
Dosage and administration
Please refer to Table 1
Dosage and Treatment Schedule
 
TABLE 1
 
Species
Product
No. of Pipettes
Imidacloprid (mg/kg bw)
Cats
   
Less than 4 kg bodyweight
Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits
1 x 0.4 ml
Minimum of 10
4 kg and greater
Advantage 80 mg Spot-On Solution for Large Cats and Pet Rabbits
1 x 0.8 ml
Maximum of 20
Dogs
   
Less than 4 kg bodyweight
Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits
1 x 0.4 ml
Minimum of 10
4 kg to less than 10 kg
Advantage 100 Spot-On Solution for Dogs
1 x 1.0 ml
Minimum of 10
10 kg to less than 25 kg
Advantage 250 Spot-On Solution for Dogs
1 x 2.5 ml
Minimum of 10
25 kg to less than 40 kg
Advantage 400 Spot-On Solution for Dogs
1 x 4.0 ml
Minimum of 10
40 kg and greater
Advantage 400 Spot-On Solution for Dogs
2 x 4.0 ml
Minimum of 10
Rabbit
   
Adult less than 4 kg bodyweight (older than 10 weeks)
4 kg and greater
Advantage 40 mg Spot-On Solution for Small Cats, Small Dogs and Pet Rabbits
Advantage 80 mg Spot-On Solution for Large Cats and Pet Rabbits
1 x 0.4 ml 1x 0.8 ml
Minimum of 10 Maximum of 20
Treatment should be repeated after four weeks. Treatment of nursing bitches and queens controls flea infestations on both dam and offspring.
Fleas are killed within one day following treatment. One treatment prevents further flea infestation on dogs and cats for up to four weeks and on rabbits for up to one week. Should re-treatment be necessary earlier than four weeks, do not treat more frequently than weekly.
Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment. To aid reduction in environmental challenge, the additional use of a suitable environmental treatment against adult fleas and developing stages is recommended. In order to reduce further the environmental challenge, it is recommended that all cats, dogs and rabbits in the household are treated.
The product remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). However, re-treatment may become necessary, depending on the presence of fleas in the environment. In these cases do not treat more frequently than once weekly.
In the case of biting louse infestation in dogs, a veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.
Method of Administration
Remove one tube from the package. Hold the tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube. See Figure 1.
Advantage - Opening pipette
Figure 1: Opening a tube
Administration to the Cat/Rabbit
Part the hair on the pet’s neck at the base of the skull until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. See Figure 2. Correct application will minimise the opportunity for the animal to lick off the product. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.
Advantage - Application to cat and rabbit
Figure 2: Administration to the cat/rabbit
For dogs of less than 25kg body weight
With the dog in the standing position, part the coat between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. See Figure 3.
Advantage - Application to dog (1)
Figure 3: Administration to dogs up to 25kg
For dogs of 25 kg body weight and greater
The dog should be standing for easy application. The entire contents of the tube should be applied evenly to 3 or 4 spots all located at different application sites along the dog's backline from the shoulder to the base of the tail. At each spot, part the coat until the skin is visible. Place the tip of the tube on the skin and gently squeeze the tube to expel a portion of its contents directly onto the skin. Do not apply an excessive amount of solution at any one spot, as that could cause some of the product to run down the animal's side. See Figure 4.
Advantage - Application to big dog (1)
Figure 4: Administration to dogs over 25kg
For all dogs
Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run down the side of the dog. The product is bitter tasting and salivation may occasionally occur if the dog licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimize the opportunity for the dog to lick the product. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.
Use During Pregnancy and Lactation
No reproductive toxic effects have been observed in rats and no primary embryotoxic or teratogenic toxic effects have been observed during the studies on rats and rabbits. Studies on pregnant and lactating bitches, queens and does together with their offspring are limited. Evidence so far indicates that no adverse effects are to be expected in these animals.
           
 
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  Date updated: 24 October 2012