As with any antiparasiticide frequent and repeated use of antiprotozoals from the same class may lead to the development of resistance.

It is recommended to treat all calves in a pen.

Hygienic measures may reduce the risk of bovine coccidiosis. It is therefore, recommended to improve concomitantly the hygienic conditions in the concerned facility, particularly dryness and cleanliness.

To obtain maximum benefit, animals should be treated before the expected onset of clinical signs, i.e. in the prepatent period.

To alter the course of an established clinical coccidial infection, in individual animals already showing signs of diarrhoea, additional supportive therapy may be required.

A threefold overdose is well tolerated by calves without signs of intolerance.

Consumer Safety Withdrawal period: Meat and offal: 63 days Not permitted for use in lactating animals producing milk for human consumption.

User Safety: Wash any splashes from skin or eyes immediately with water.

Environmental Safety: For environmental reasons:

• Do not use in calves weighing more than 80 kg bodyweight.

• Do not use in fattening units such as veal or beef calves.

The major metabolite of toltrazuril, toltrazuril sulfone (ponazuril), has been shown to be both persistent (half-life >1 year) and mobile in soil and to be toxic to plants.

In order to prevent any adverse effects on plants and possible contamination of groundwater manure from treated calves must not be spread onto land without dilution with manure from untreated cows. Manure from treated calves must be diluted with at least 3 times the weight of manure from mature cows before it can be spread onto land.

Any unused product or waste materials should be disposed of in accordance with national requirements.