Do not exceed the recommended dose or treat animals for more than 5 consecutive days. Tolerance trials in horses and cattle confirmed excellent tolerance at twice the recommended dose.

Do not administer other NSAIDs concurrently or within 24 hours of each other.

Avoid intra-arterial injection, which may result in collapse.

Avoid use in dehydrated, hypovolaemic or hypotensive animals as there is a potential risk of increased renal toxicity.

Use is contra-indicated in animals suffering from cardiac, hepatic or renal disease, where there is the possibility of gastro-intestinal ulceration or bleeding, or where there is evidence of a blood dyscrasia or hypersensitivity to the product.

Do not administer to racehorses within 8 days of racing.

Monitor drug compatibility closely where adjunctive therapy is required. As with other NSAIDs, Binixin Injection may potentiate the effects of Warfarin and other drugs.

Due to their common mode of action, flunixin may potentiate and be potentiated by other NSAIDs which act by interfering with prostaglandin synthesis.

Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs to produce an increase in non-bound pharmacologically active concentrations, which can lead to toxic effects. Use in any animal less than 6 weeks of age or in aged animals may involve additional risk. If such use cannot be avoided, animals may require a reduced dosage and careful clinical management.

It is preferable that flunixin is not administered to animals undergoing general anaesthesia until fully recovered.

Concurrent administration of potentially nephrotoxic drugs should be avoided.

NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infections, appropriate concurrent anti-microbial therapy should be instigated.

Prolonged use of NSAIDs, including flunixin, may predispose or lead to gastrointestinal irritation, and in severe cases, ulceration.

Repeated use in equine colic may mask signs of pain.

Avoid accidental self injection.

Avoid contact with the eyes. In the case of accidental contact with the eyes, rinse immediately with plenty of eater and seek medical advice. To avoid possible sensitisation reactions, avoid contact with skin. Gloves should be worn during administration. Wash hands after use.

The product may cause reaction in sensitive individuals. If you have a known hypersensitivity to non-steroidal anti-inflammatory products, do not handle the product. Reactions may be serious.

Not to be used in horses intended for human consumption.

Treated horses may never be slaughtered for human consumption.

The horse must have been declared as not intended for human consumption under national horse passport legislation.

Meat:

Animals may not be slaughtered for human consumption during treatment.

Cattle may be slaughtered for human consumption only 8 days after the last treatment.

Milk:

Milk from lactating cows should be discarded during treatment. Milk from cows should only be taken for human consumption from 12 hours following cessation of treatment.