Observe aseptic precautions.

When high doses are to be employed the animal should be fasted for some hours beforehand.

Sedated animals should remain under observation until normal. Segregate sedated animals.

Concurrent administration of adrenoceptor stimulants is not recommended.

It must be noted that the swallowing reflex is reduced during the period when the action of the drug is at its peak.

In the event of respiratory failure manual compression of the thorax is usually sufficient to restore normal respiration.

Use with care in elderly or debilitated patients which may be adversely affected by profound cardiovascular changes.

Caution is required when pulmonary disease is present.

Tympany should be prevented in recumbent cattle by sternal recumbency.

For operations in lateral or dorsal recumbency, lower head and neck to prevent inhalation of ruminal contents.

Maintain recumbent and drowsy animals in the shade. In case of accidental overdosage leading to respiratory failure, cold water douches and artificial respiration are indicated.

After dose levels 3 and 4 cattle are likely to remain drowsy for several hours and should be kept in the shade.

Following intravenous injection in horses a transient rise and fall in blood pressure may be seen.

With horses the usual precautions required in handling should always be observed even when a high dose of xylazine has been given.

The concurrent intravenous use of potentiated sulphonamides with alpha-2 agonists has been reported to cause cardiac arrhythmias which may be fatal. Whilst no such effects have been reported with Rompun, it is recommended that intravenous administration of Trimethoprim/Sulphonamide containing products should not be undertaken when horses have been sedated with xylazine.

In cats and dogs if the stomach is full, vomiting occurs before sedation is complete. This is an advantage if general anaesthesia is to follow. The emetic effect is reduced by fasting for 6 to 24 hours beforehand.

In the cat and dog, because of the emetic effect which is sometimes produced, do not use Rompun in mechanical complications of the alimentary tract e.g. obstruction of the oesophagus, gastric torsion or hernia.

Premedication with atropine in cats and dogs may reduce salivation and bradycardia effects.

Animals must not be slaughtered for human consumption during treatment.

Cattle: Meat: 6 days; Milk: 24 hours

Horse (meat):

Not to be used in horses intended for human consumption.

Treated horses may never be slaughtered for human consumption.

The horse must have been declared as not intended for human consumption under national horse passport legislation.

Xylazine is a powerful alpha-adrenergic agonist acting primarily on alpha-2 receptors.

Care should be taken to avoid accidental self-injection (see above).

It is recommended that, once the required dose has been withdrawn from the vial, the needle should be kept guarded until the product is administered. Alternatively it should be removed from the syringe and immediately inserted in the injection site, and the syringe should then be connected to it.

In the event of accidental self-administration, seek medical advice and show the product label and other product literature. DO NOT DRIVE as variations in blood pressure may be seen.

Wash splashes from skin and eyes immediately.