NOAH Compendium of Animal Medicines: Rompun Dry Substance

Rompun Dry Substance

Dosage and administration

To avoid accidental self injection the following procedure should be adopted; use 2 sterile needles one to fill syringe from bottle and one to inject the patient. Once the required dose has been withdrawn from the vial, the syringe should be removed from the needle. A separate sterile needle should be inserted into the injection site and the syringe connected to it. The needles should be discarded into a closed container.

Syringes and needles must be sterile. Clean area of injection site and swab with spirit.

Rompun Dry Substance is dissolved in the solvent provided and given by intramuscular or intravenous injection in the horse and by intramuscular injection only in zoo animals. Intravenous injection in the horse should be slow, taking from one to two minutes to administer.

Dissolving one bottle of Rompun Dry Substance in 10 ml of solvent yields a 5% (50 mg/ml) solution and in 5 ml a 10% (100 mg/ml) solution.

Horse
	mg/kg	ml 5% solution	ml 10% solution
		per 50 kg BW	per 50 kg BW
i/v	0.6–1.0	0.6–1.0	0.3–0.5
i/m	2.4–3.0	2.4–3.0	1.2–1.5

Intravenous injection should be slow taking 1-2 minutes

These dosages are effective in most cases.

Dosage depends on the degree of sedation required and the response of the animal. Nervous or highly excitable horses generally require a slightly higher dose. Experience has shown that older horses and those that have undergone severe exertion before treatment respond more readily to Rompun.

Depending on the dosage, light to deep sedation with individually variable analgesia is obtained. The horse does not become recumbent.

If it is desirable to achieve the maximum possible sedation the intramuscular route and the highest dose rate are recommended.

Animals should not be disturbed until Rompun has taken its full effect. This is usually obtained within 5 minutes of intravenous injection and 15 minutes of intramuscular injection. Sedation lasts for approximately 20 minutes.

If the required depth of sedation is not achieved, it is unlikely that repetition of the dose will prove more effective. It is advisable to allow complete recovery, repeating the procedure after 24 hours using a higher dose rate.

For operations and painful procedures, additional local or regional anaesthesia should be used.

Zoo Animals

The dose rates are variable. Veterinary surgeons are advised to contact the company prior to use in species other than those shown below.

	mg/kg	ml 5% solution per 10 kg BW	ml 10% solution per 10 kg BW
Roe deer (Capreolus capreolus)	2–3	0.4–0.6	0.2–0.3
Red deer (Cervus elaphus)	2–3	0.4–0.6	0.2–0.3
Fallow deer (Dama dama)	6–8	1.2–1.6	0.6–0.8

Before zoo animals are approached after treatment 20 minutes should be allowed to elapse and full sedation will last approximately 30 minutes.

It should not be assumed that the animal is fully sedated and personal precautions should not be neglected.

Rompun dry substance can be used to control cattle destined for slaughter under the Bovine Spongiform Encephalopathy Order.

Sedated or immobilized animals should remain under supervision until normal. They should be segregated to avoid bullying by others.

Use During Pregnancy and Lactation

Do not use in the latter stages of pregnancy except at parturition. As the safety of xylazine use during organogenesis has not been fully demonstrated by current methods, it should be used with caution during the first month of pregnancy.