Rompun Dry Substance: Contra-indications, warnings, etc
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Rompun Dry Substance
Contra-indications, warnings, etc
Not for use in zoo animals intended for human consumption.
Caution is required when pulmonary disease is present or suspected.
In recumbent ruminants tympany should be prevented by maintaining sternal recumbency.
For operations on ruminants in lateral or dorsal recumbency it is advisable to lower the head and neck in order to avoid inhalation of saliva or ruminal fluids.
It must be noted that the swallowing reflex is reduced during the period when the action of the drug is at its peak.
When high doses are to be employed the animal should be fasted for some hours beforehand.
After high doses animals are likely to remain drowsy for several hours and should be kept in the shade.
In case of accidental overdosage leading to respiratory failure cold water douches and artificial respiration are indicated.
In the event of respiratory failure manual compression of the thorax is usually sufficient to restore normal respiration.
Following intravenous injection in horses there is a transient rise followed by a fall in blood pressure.
With horses and zoo animals the usual precautions required for handling should always be observed even when a high dose of Rompun has been given.
Transient hyperglycaemia is a common finding after Rompun sedation.
Operator Warnings
Xylazine is an alpha adrenoceptor agonist acting primarily on alpha-2 receptors.
Care should be taken to avoid accidental self-administration (see above).
It is recommended that once the required dose has been withdrawn from the vial, the needle should be kept guarded until the product is administered. Alternatively, it should be removed from the syringe and immediately inserted into the injection site and the syringe should then be connected to it.
Wash splashes from skin and eyes immediately.
In the event of accidental self-administration, seek medical advice and show the label and other product literature to medical staff. DO NOT DRIVE as changes in blood pressure may occur.
Information for Doctors
1.Human sedative dose: 0.3-0.6 mg/kg (1-2 ml Rompun 2%; 0.25-0.5 ml Rompun Dry Substance 10% solution).
2.Xylazine is an alpha adrenoceptor agonist whose toxicity may cause clinical effects including sedation, respiratory depression and coma, bradycardia, hypotension and hyperglycaemia. Ventricular arrhythmias have also been reported.
3.Treatment should be supportive with appropriate intensive therapy.
Withdrawal Periods
Horse
Meat:
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.
Zoo Animals: Contra-indicated for animals intended for human consumption.
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Date updated: 11 June 2008