Contra-indications, warnings, etc
Do not treat kittens less than 10 weeks of age.
Do not treat puppies less than 7 weeks of age.
Do not use in the case of known hypersensitivity to the active substances or to any of the excipients.
Ticks will be killed and fall off the host within 24 to 48 hours after infestation without having had a blood meal, as a rule. An attachment of single ticks after treatment cannot be excluded. For this reason, a transmission of infectious diseases by ticks cannot be completely excluded if conditions are unfavourable.
As in all long term topical products, periods of excessive seasonal hair shedding may lead to transient slight reduction of efficacy by loss of hair-bound portions of the active ingredients. Replenishment from the collar starts immediately so that full efficacy will be re-established without any additional treatment or collar replacement.
For optimum control of flea problems in heavily infested households it may be necessary to treat the environment with a suitable insecticide.
The product is water resistant; it remains effective if the animal becomes wet. However, prolonged, intense exposure to water or extensive shampooing should be avoided as the duration of activity may be reduced. Studies show that monthly shampooing or water immersion does not significantly shorten the 8 months efficacy duration for ticks after redistribution of the active substances in the coat whereas the product’s flea efficacy gradually decreased, starting in the 5th month.
Occasionally mild behavioural disorders that may include scratching at the application site may be observed in animals that are not used to wearing collars on the first few days after fitting. Ensure that the collar is not fitted too tightly.
Mild application site reactions such as pruritus, erythema and hair loss may occur. These have been reported as rare in dogs and uncommon in cats and usually resolve within 1 to 2 weeks without the need for collar removal. In single cases, a temporary collar removal may be recommended until the symptoms have disappeared.
In very rare cases in dogs and rare cases in cats, application site reactions such as dermatitis, inflammation, eczema or lesions may occur and in these instances, collar removal is recommended.
Also, in rare case in cats and dogs, slight and transient reactions as depression, change of food intake, salivation, vomiting and diarrhoea might occur initially.
As in other topical applications, allergic contact dermatitis might occur in hypersensitive animals.
The frequency of possible adverse effects is defined using the following convention:
very common (affects more than 1 animal in 10)
common (affects 1 to 10 animals in 100)
uncommon (affects 1 to 10 animals in 1,000)
rare (affects 1 to 10 animals in 10,000)
very rare (affects less than 1 animals in 10,000)
not known (frequency cannot be estimated from the available data).
Due to the nature of the collar, overdosage is unlikely and signs of overdosage are not to be expected.
An overdosage of 5 collars around the neck was investigated in adult cats and dogs for an 8 month period, and in 7 week old puppies and 10 week old kittens for a 6 month period and no other adverse effects were observed than those already described in this section.
In the unlikely event of the animal eating the collar mild gastrointestinal symptoms (e.g. loose stool) may occur.
Keep the bag with the collar in the outer packaging until use.
As with any veterinary medicinal product, do not allow small children to play with the collar, or to put it into their mouths. Pets wearing the collar should not be allowed to sleep in the same bed as their owners, especially children.
People with known sensitivity to the ingredients of the collar should avoid contact with the collar.
Immediately dispose of any remnants or cut-offs of the collar (see Dosage and administration section).
Wash hands with cold water after fitting the collar.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
This product should not enter water courses as it may be dangerous for fish and other aquatic organisms.