Introduction

vet06001

Company name: Bimeda

Address: A division of Cross Vetpharm Group UK Limited

Bryn Cefni Industrial Park,

Llangefni,

Anglesey LL77 7XA.

Telephone: 0800 526769

Fax: 01248 725416

Email: sales@bimeda.co.uk

Presentation

A ready to administer oral paste for horses and other equines. Each 28.5g syringe contains 11.4g pyrantel embotape USP as active ingredient. Also contains butylated hydroxytoluene.

Uses

Pyrantel embonate is a broad spectrum anthelmintic. Pyrantel embonate is indicated for use in the horse for the control and treatment of adult infections of large and small strongyles, Pinworms, Roundworms, Tapeworms.

Pyrantel embonate has a broad spectrum of activity, including activity against:

Large strongyles:Stronglylus vulgaris, S. edentatus, S. equinus.

Small strongyles: Trichonema spp. (Cyathostomes), Triodontophorus spp.

Pinworms: Oxyuris equi, Probstmayria vivipara.

Large roundworms: Parascaris equorum.

Tape worms: Anoplocephala perfoliata

Dosage and administration

Control and treatment of Strongyles, Oxyuris and Parascaris:

Embotape should be used at a dose rate of 19 mg pyrantel embonate per kg bodyweight. The dosing programmes are as follows:

a) Foals (1-8 months of age): dose every 4 weeks.

b) Horses (over 8 months of age): dose every 6-8 weeks, but during the summer and autumn when at grass dose every 4-6 weeks. Always dose 3-4 days before turning out after in wintering.

c) Suckler mares: It has been shown that reduction of strongyle challenge to the suckling foal at pasture can be achieved by using clean pasture (re-seeded or not grazed the previous year by horses), dosing the mare 3-4 days before turning out and then at intervals of 2-4 weeks until the end of Autumn. Ideally mares with foals should go out to ‘clean’ pasture or, if this is not possible, delay turning them out until June.

The prescribed amount of Embotape is deposited on the tongue of the animal and the animal allowed to swallow. The complete content of one syringe contains 11.4g pyrantel embonate (6 graduated doses of 1.9g) in 28.5g paste and is sufficient for the treatment of 600kg bodyweight. Each graduation of the syringe is sufficient for the treatment of 100kg body-weight.

Control and treatment of Anoplocephala (Tapeworm):

Embotape should be used at a dose rate of 38mg pyrantel embonate per kg bodyweight (i.e. twice the dose used for stronglyes). The need for re-treatment may vary, but if considered necessary, should be carried out after an interval of 6 weeks.

Warnings during administration:

Direct contact with the skin should be avoided. Wash hands and any other parts of the body which comes into contact with the product after use. Avoid handling the product if you know you are hypersensitive to pyrantel.

Contra-indications, warnings, etc

Not intended for use in horses intended for slaughter for human consumption. Not for use in foals less than 4 weeks of age. Contraindicated in known sensitivity to pyrantel and in severely debilitated animals.

Pyrantel embonate is safe for horses and ponies of all ages, including sucklings, pregnant mares and studs. Impaction of the small intestine may occur in foals, infected with high numbers of Parascaris equorum. Symptoms (colic) may be seen as soon as 30 minutes after treatment.

The same syringe should only be used to dose two animals if they are both healthy and are either running together, or are on the same premises and in direct contact with each other.

Overdose:

Pyrantel embonate is of low accurate oral toxicity. Oral doses of up to 2000mg/kg bodyweight in mice and rats and 1000mg/kg in dogs have produced no evidence of toxicity.

Pyrantel embonate, at dosages of up to 60mg/kg bodyweight, as base, (some 20 times the standard therapeutic dose) had no adverse effects on horses, ponies or foals. Monitoring included haematological parameters, and serum cholinesterase and glutamic oxaloacetic transaminase levels.

Use during pregnancy and lactation:

Embotape is safe to give to pregnant and lactating mares provided the recommendations are followed.