May be used in conjunction with antibiotics and/or sulphonamides, bronchodilators etc. Bisolvon has been shown to increase mucocillary clearance in calves suffering from respiratory disease.

When Bisolvon is administered simultaneously with oxytetracycline in cattle and pigs, the levels of the antibiotic in the bronchial mucus are considerably increased (by more than 40%). The clinical significance of this action is uncertain.