Introduction

Company name: Boehringer Ingelheim Limited

Address: Ellesfield Avenue

Bracknell

Berkshire RG12 8YS

Telephone: Sales & Marketing Enquiries 01344 746959

Telephone: Technical Enquiries 01344 746957

Fax: 01344 741349

Presentation

White powder for oral solution or addition to feed, containing 10 mg bromhexine hydrochloride per gram as active ingredient.

Uses

As an aid to the treatment of respiratory disease in cattle, pigs, dogs and cats where mucus is a complicating factor.

Cattle, calves, pigs, piglets, dogs and cats

- all respiratory infections.

Dosage and administration

For oral administration in the feed or drinking water. Add to feed or drinking water immediately before administration. Discard any remaining medicated feed or drinking water which is not consumed within 24 hours.

Table 1: Bisolvon Powder Dosage Guide
Species	Dose of Bromhexine Hydrochloride (mgkg−-1)	Total Daily Dose of Powder (g)	Frequency	Duration of treatment (d)
Cattle	0.5 mg/kg	5 g/100 kg	once daily	5 days
Pigs	0.2-0.5 mg/kg	2-5 g/100 kg	once daily	5 days
Dogs	2.0 mg/kg	2g/10 kg	twice daily	5 days
Cats	1.0 mg/kg	0.5g /5kg	once daily	7 days
Species	Bodyweight (kg)	Dose of Bisolvon Powder (g)	No. of white (5 g) scoops	No. of blue (0.5g) scoops
Calves	100	5	1	-
Cattle	400	20	4	-
Pigs	100	2-5	½-1	-
Dogs	5	0.5	-	1
	15	1.5	-	3
Cats	5	0.5	-	1

The 100g and 500g packs contain a white scoop, delivering approximately 5 g when filled level. The sachet pack contains blue measuring scoops delivering approximately 0.5g when filled level, suitable for small animal doses.

Table 1 illustrates use of these measures on a per scoop basis.

Contra-indications, warnings, etc

Not for use in cows producing milk for human consumption.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority. Avoid contact with skin and eyes. In case of accidental eye contact, flush the affected eye with copious amounts of clean running water. Wash hands and exposed skin after administering the product.

Withdrawal Periods

Cattle - 2 days

Pigs - 0 days

Pharmaceutical precautions

Store below 25°C. Store in a dry place.

Keep out of the reach and sight of children.

If sachets are to be used over a period of a few days, they should be resealed as well as possible between doses. Keep the container in the outer carton. Discard any unused material.

Legal category

POM-V

Packaging Quantities

40×5 g sachets.

Further information

May be used in conjunction with antibiotics and/or sulphonamides, bronchodilators etc. Bisolvon has been shown to increase mucocillary clearance in calves suffering from respiratory disease.

When Bisolvon is administered simultaneously with oxytetracycline in cattle and pigs, the levels of the antibiotic in the bronchial mucus are considerably increased (by more than 40%). The clinical significance of this action is uncertain.

Marketing authorisation number

Vm 00015/4072.