Company name: Boehringer Ingelheim Limited
Address: Ellesfield Avenue
Bracknell
Berkshire RG12 8YS
Telephone: Sales & Marketing Enquiries 01344 746959
Telephone: Technical Enquiries 01344 746957
Fax: 01344 741349
Equitrim Equine Oral Paste
Company name: Boehringer Ingelheim Limited
Address: Ellesfield Avenue
Bracknell
Berkshire RG12 8YS
Telephone: Sales & Marketing Enquiries 01344 746959
Telephone: Technical Enquiries 01344 746957
Fax: 01344 741349
A creamy white paste with broad antibacterial activity. Presented in disposable dial-a-dose plastic syringes for oral administration to horses. Each 45 g syringe contains: Trimethoprim 2.6 g and Sulphadiazine 13.0 g and as antimicrobial preservatives methyl hydroxybenzoate 8 mg and propyl hydroxybenzoate 9 mg.
For the oral treatment of a wide range of equine bacterial infections.
Equitrim is a broad spectrum antibacterial, active against a wide range of Gram-positive and Gram-negative organisms. Together the active ingredients produce a double blockade of folinic acid synthesis in bacteria resulting in a level of activity much greater than that obtained from either drug alone.
In vitro Equitrim is effective against Escherichia coli, Corynebacterium equi, Staphylococcus spp., and Streptococcus spp. When susceptible organisms are present Equitrim Equine Paste may be effective in treating the following conditions:
Respiratory tract infections including pneumonia, pleurisy and strangles.
Alimentary tract infections including diarrhoea.
Wounds, septicaemia and general infections.
Dosage
The daily dose is 30 mg combined active ingredients per kg bodyweight. Each syringe contains one daily dose for a 500 kg horse. Each division on the dial-a-dose plunger provides sufficient medication to treat 50 kg of bodyweight.
Treatment should be continued for up to 5 days or until 2 days after symptoms have resolved, up to a maximum of 5 days.
Administration
Adjust screw gauge on dial-a-dose plunger to the bodyweight of the horse. Remove cap from nozzle. Place nozzle in corner of mouth. Depress plunger depositing paste on upper surface of tongue.
Do not use the same syringe to treat more than one animal unless horses are kept together or are in direct contact with each other.
To ensure a correct dose, bodyweight should be determined as accurately as possible to avoid underdosing.
Contra-indications, warnings, etc
Withdrawal Period
Not to be used in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.
Do not use in horses with hepatic damage, blood dyscrasias, or known hypersensitivity to the active ingredients.
The use of trimethoprim-sulphadiazine combinations during pregnancy and lactation has not been shown to cause any adverse effects or foetal abnormalities.
There is potential for interaction with electrolyte solutions, potassium chloride and intravenous glucose infusion.
The combination has a wide safety margin. There are no antidotes and treatment is symptomatic.
For animal treatment only.
Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.
Store below 25°C. Do not freeze. Keep out of the reach and sight of children. For animal treatment only. Wash hands after use.
White high density polyethylene disposable dial-a-dose syringes containing 45 g of creamy white paste in packs of 5 syringes.
Drug absorption may be greater if food is withheld for a few hours prior to dosing.
Pharmacodynamic properties
Sulfadiazine (SDZ) inhibits the incorporation of para-aminobenzoic acid into folic acid, and trimethoprim (TMP) inhibits the enzyme dihydrofolate reductase (DHFR) which converts dihydrofolic acid into tetrahydrofolic acid. Trimethoprim and sulfadiazine act together synergistically with a double-blockage mode of action. The combination is bactericidal, inhibiting sequential steps in the synthesis of purines which are required for DNA synthesis. TMP-SDZ combinations have a broad bactericidal action against many gram-positive and gram-negative aerobic bacteria and a large proportion of anaerobic bacterial.