Introduction

vet00301

Company name: Boehringer Ingelheim Limited

Address: Ellesfield Avenue

Bracknell

Berkshire RG12 8YS

Telephone: Sales & Marketing Enquiries 01344 746959

Telephone: Technical Enquiries 01344 746957

Fax: 01344 741349

Presentation

Each UBRO RED Dry Cow intramammary injector contains:

Framycetin sulphate	100 mg
Penethamate hydriodide	100 mg
Procaine penicillin	300 mg

suspended in a white sterile slow-release ointment base.

Uses

UBRO RED Dry Cow contains a combination of an aminoglycoside, a penicillin ester and a penicillin salt, which gives a wide spectrum of antibacterial activity suspended in a slow-release base specifically designed for dry cow therapy. Routine dry cow therapy is established as an important part of mastitis control, in conjunction with teat dipping and other managemental factors. UBRO RED Dry Cow is indicated for the management of subclinical infections present at drying off and to assist in preventing new infections occurring during the dry period. In the case of E. coli infections, this results in a reduction in the incidence of clinical mastitis during the first 100 days of the following lactation. Following infusion, framycetin sulphate and the penicillin components are released slowly by the base and retained in the udder over a prolonged period. Penethemate hydriodide has a similar range of activity as procaine penicillin and, in-vitro, micro-organisms sensitive to the procaine penicillin/penethamate hydriodide combination include streptococci, penicillin-sensitive staphylococci, Arcanobacterium pyogenes, Corynebacteria bovis and anaerobic micrococci. The penicillin component of UBRO RED Dry Cow will remain above the M.I.C.'s of these micro-organisms for up to 3 weeks in most dry udders. Micro-organisms, sensitive in-vitro to framycetin include penicillin resistant staphylococci, E coli and other Gram-negative bacteria. The framycetin component of UBRO RED Dry Cow will remain above the M.I.C.'s of these micro-organisms for up to 14 weeks in most dry udders, though the effect of "bagging up" will reduce the concentration of framycetin to insignificant levels from a few days before calving

Dosage and administration

One injector per quarter at drying off.

Each quarter should be infused with the contents of one injector immediately after the last milking of lactation. Before infusion the teats should be thoroughly cleaned and disinfected and care should be taken to avoid contamination of the injector nozzle. Following infusion, the teats should be dipped or sprayed with a teat disinfectant.

Contra-indications, warnings, etc

For animal treatment only.

Not to be used in the lactating cow.

Not intended for use within 28 days of calving. Milk for human consumption may only be taken from 84 hours (7 milkings) after calving.

If calving occurs before 28 days after last treatment, milk for human consumption may only be taken after 28 days plus 72 hours from the last treatment.

Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 28 days from last treatment.

Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.

(1) Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations.

(2) Handle the product with great care to avoid exposure taking all recommended precautions.

(3) If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.

(4) Wash hands after use.

Keep out of the reach and sight of children.

Pharmaceutical precautions

Do not store above 25°C.

The syringe must only be used once. Part used syringes must be discarded. Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority.