The vaccine virus is excreted by vaccinated birds, can spread to susceptible birds and can be detected in unvaccinated birds 4-7 days later. In susceptible birds (i.e. without MDA) this may result in significant immunosupression and bursal damage.

The use of this vaccine is contraindicated in eggs coming from layer flocks not vaccinated according to an IBD immunisation program.

In-ovo injection equipment must be used for administration. The User’s Manual of the equipment must be followed strictly. Device(s) used for the reconstitution of the vaccine and for injection should be sterile and free from any residues of chemical disinfectant.

Before every in ovo application the vaccination technique has to be checked by use of a colour solution. The vaccine must be inoculated directly into the amniotic cavity or the embryo. A stab vaccinator may be used for in ovo vaccination. It must be guaranteed that the instrument administers the necessary vaccine dose into the amniotic cavity or the embryo reliably. Furthermore, the manufacturer's instructions have to be observed, especially with regard to needle length and air pressure. For cleaning of the instrument only products approved by the manufacturer may be used.

The vaccine contains a strain of "intermediate-plus" virulence.

In birds without MDA the inoculation of the vaccine results in significant immunosupression and bursal damage. Therefore, it is not recommended to vaccinate eggs coming from flocks with day-old MDA titre levels lower than 3,000 ELISA units.

Preliminary survey to be used to estimate MDA level of the chicks: 20, day-old chicks originating from the same breeding flock should be sampled to measure their serological status to IBDV. The results of this sampling will indicate if the MDA level can be expected to be at least 3000 ELISA units in the hatches of the following 4 weeks from this flock, and therefore that they are suitable for Cevac® Transmune vaccination. According to results and needs, this survey has to be repeated at different times of the laying period.

To control the spread of the virus, the immunisation devices used for injection and the hatchery premises should be decontaminated after vaccination.

Chickens from vaccinated eggs should not be mixed with chickens from unvaccinated eggs. Precautions should be taken regarding between-house spread. Whole site vaccination is recommended. Poultry houses should be decontaminated between batches of chickens.

Satisfactory protection can be achieved only in properly developed embryos at the 18th day of hatching. It is suggested to candle the eggs to be injected and to separate and discard dead embryos.

In vaccinated chickens, mild to moderate lymphocyte depletion is observed after the vaccine take, which is maximal at around 7 days after vaccine take. After 7 days, this depletion decreases and is followed by lymphocyte repopulation and regeneration of the bursa of Fabricius.

It is advised that vaccinating personnel wash and disinfect hands after use.

Do not use in eggs intended for hatching of layers or broiler breeders.

No information is available on the compatibility of this vaccine with any other. Therefore the safety and efficacy of this product when used with any other (either when used on the same day or at different times) has not been demonstrated.

Meat - Zero days

For animal treatment only. Keep out of reach and sight of children.