Do not use in pregnant and lactating bitches.

Do not use in breeding dogs.

Do not use in cases of hypersensitivity to enalapril.

Do not use in dogs with evidence of cardiac output failure (e.g. aortic stenosis, mitral stenosis, obstructive cardiomyopathy).

Pre-renal azotemia generally results from hypotension due to cardio-vascular insufficiency. Substances that deplete blood volume, such as diuretics, or with a vasodilator effect, such as ACE inhibitors, may contribute to lowering systemic blood pressure. This may create a hypotensive state or exacerbate an existing hypotensive situation and result in pre-renal azotemia.

Dogs with no detectable renal disease may develop mild and transient increases in blood urea nitrogen or serum creatinine when the product is administered concomitantly with a diuretic.

The diuretic and/or enalapril dose should be reduced if clinical signs of hypotension or azotemia appear or if the blood concentration of urea nitrogen and/or creatinine increases significantly above the values observed before treatment. Should clinical signs of overdose occur (azotemia) after the dose is increased from once daily to twice daily, the dose should be decreased to once daily.

Normal dogs dosed at 15 mg/kg/day for up to 1 year showed no adverse effects. This means that overdose symptoms generally appear at more than 30 times (at 0.5 mg/kg) or 15 times (at 1 mg/kg) the recommended dosage during one year.

Clinical signs reported include hypotension, azotemia, and increased concentration of urea and/or creatinine. Treat symptomatically.

Hypotension and its consequences (e.g. azotemia) can occur at the start of the therapy (in less than 2 % of the treated dogs). Diarrhoea, vomiting, lethargy, dizziness, disorientation and in-coordination can also occur.

Sodium chloride may decrease the hypotensive effect of enalapril.

Concurrent use with NSAIDs may increase the risk of renal toxicity.

Wash hands after use.

In case of accidental ingestion, seek medical advice showing the label to the doctor or medical practitioner.

For animal treatment only. Keep out of reach and sight of children.