In case of hypokalaemia, potassium supplements can be administered concomitantly with Prilenal®. Plasma potassium should be assessed prior to treatment and periodic monitoring should be continued.

In humans, in cases of renal impairment, the concomitant use of enalapril with aldosterone-antagonists can lead to hyperkalaemia. Therefore, both the renal function and plasma potassium are closely monitored in such patients. In absence of data in dogs, such recommendations should be followed in the target species.

Therapy with diuretics should be started at least 1 day prior to initiating treatment with enalapril. Renal function should be assessed prior to, and for 2-7 days after starting treatment. Periodic monitoring of renal function should be continued.