Introduction

vet00501

Company name: CEVA Animal Health Ltd

Address: 90 The Broadway

Chesham

Buckinghamshire

HP5 1EG

Telephone: 01494 781510

Fax: 01494 781519

Email: cevauk@ceva.com

Website: www.ceva.uk.com

Presentation

An aqueous solution containing 125 mg tiamulin hydrogen fumarate per ml. Tiamvet® 12.5% solution also contains benzyl alcohol 15 mg/ml as a preservative.

Uses

Actions

Tiamulin hydrogen fumarate is a semi-synthetic diterpene antimicrobial. The mode of action is by inhibition of ribosomal protein synthesis in sensitive bacteria. It is a bacteriostatic antimicrobial and the following organisms show sensitivity in-vitro:

Brachyspira: Brachyspira hyodysenteriae, B. pilosicoli.

Mycoplasmas: Mycoplasma hyopneumoniae, M. hyorhinis, M. hyosynoviae, Ureaplasma spp.

Gram-positive: Staphylococcus spp., Streptococcus spp., Arcanobacterium pyogenes.

Gram-negative: Pasteurella spp., Klebsiella pneumoniae, Actinobacillus (Haemophilus) spp., Fusobacterium necrophorum, Bacteroides spp., Campylobacter coli, Lawsonia intracellularis.

Indications

For the treatment, prevention and control of swine dysentery caused by Brachyspira hyodysenteriae and complicated by Fusobacterium and Bacteroides spp.

Dosage and administration

The dosage is 8.8 mg of the active substance per kg body weight daily, (equivalent to 10 ml solution per 142 kg body weight) administered in the drinking water of pigs for 3 to 5 days, depending on the severity of the infection and/or the duration of the disease. To ensure an intake of 8.8 mg/kg daily it is important to know the weight of the animals to be treated and to measure accurately their drinking water consumption. Administer the calculated dose (based on the animals’ weight) in approximately one half of the daily water requirements, to ensure consumption of the correct dose. Unmedicated water should then be provided each day after the medicated water has been consumed. Where a water medicator is used the appropriate stock solution should be made up according to the makers’ instructions. Any medicated water not consumed within 24 hours should be discarded. Additionally, water intake levels should be monitored at frequent intervals during medication. Fresh solutions of Tiamvet®-medicated drinking water should be made up each day.

Contra-indications, warnings, etc

Do not administer products containing monensin, salinomycin or narasin during or for at least 7 days before or after treatment. Severe growth depression or death may result.

Special warnings for each target species

In order to avoid interactions between tiamulin and the incompatible ionophores monensin, narasin and salinomycin, the feed mill supplying the feed should be notified that tiamulin will be used and that these products should not be included in the feed or contaminate the feed.

The feed should be tested for the ionophores prior to use if there is any suspicion that contamination of the feed might occur. If an interaction does occur, stop tiamulin water medication immediately and replace with fresh water. Remove contaminated feed as soon as possible and replace with feed not containing the tiamulin-incompatible ionophores.

Special precautions to be taken by the person administering the medicinal product to animals

Do not eat, drink or smoke whilst using this product.

When mixing, direct contact with the skin and eyes should be avoided by wearing impermeable rubber gloves and safety glasses.

In case of accidental eye contact, irrigate the eyes thoroughly with clean running water immediately. Seek medical advice if irritation persists.

Contaminated clothing should be removed and any splashes on to the skin should be washed off immediately. Wash hands after use.

Adverse reactions

On rare occasions erythema or mild oedema of the skin may occur in pigs following the use of tiamulin hydrogen fumarate.

Use during pregnancy and lactation

The product can be used in pregnant and lactating pigs.

Withdrawal period

Pigs (meat and offal): 2 days.

Keep out of reach and sight of children.

For animal treatment only