Syncrostim 500 IU lyophilisate and solvent for solution for injection for cattle and sheep
Equine Serum Gonadotrophin (eCG, in the past called PMSG) is a large glycoprotein secreted during pregnancy in the mare and its structure is similar to the endogenous gonadotrophin hormones: FSH and LH.
eCG exerts its effects on FSH and LH receptors of target cells distributed in the gonads: in females, eCG supports the ovarian follicular maturation by stimulating the growth and development of antral follicles. In ovine and in non-cycling bovine female, its use is recommended after a treatment for the synchronisation of œstrus with a progestagen: eCG improves follicle maturation and ovulation rate and allows synchronisation of ovulation.
In plasma, eCG declines biphasically with species terminal half-lives of 22-64 hours and 118-220 hours as measured in sheep (i.v., i.m.) and cows (i.v., i.m.) respectively.
eCG is mainly degraded in liver and kidney and eliminated in the urine.