Not to be used in horses intended for human consumption.

Not for use in animals producing milk for human consumption.

Do not administer by the intra-carotid route.

Careful consideration should be given before administering to animals exposed to stress conditions such as extreme heat, cold, high altitude or fatigue.

Following use of Chanazine 2% in cattle profuse salivation, bloat and polyuria may occur. The use of xylazine in cattle should be carefully considered in cases of cardiac aberrations, arterial hypotension/shock and renal or hepatic impairment. Tympany should be avoided in recumbent cattle by maintaining the animal in sternal recumbency. Provision should also be made for facilitating dependent drainage from the mouth to avoid inhalation asphyxia.

Side Effects such as bradycardia, cardiac arrhythmia and polyuria may occur in the horse. Following intravenous administration to horses, a transient rise followed by a fall in blood pressure usually occurs. Should be used with caution when pulmonary disease is suspected.

Profound cardiovascular effects or exacerbated side effects specified above may result from overdosage. Cattle are 10 times more sensitive than horses. Do not repeat the dose in the event of unsatisfactory response. Repeat on the following day with recalculated dosage.

Vomiting is commonly observed in dogs and cats following use of the preparation. Pain may occur at the injection site following intramuscular administration in cats and dogs, massage injection site well following administration.

Chanazine 2% should not be administered in the later stages of pregnancy because of the risk of inducing premature parturition. As the safety of xylazine use during organogenesis has not been fully demonstrated by current methods it should be used with caution during the first month of pregnancy.

In larger animals xylazine is not an ideal sedative for Caesarean section because of its oxytocic effect which impedes uterine suturing.

Animals must not be slaughtered for human consumption during treatment. Cattle may be slaughtered for human consumption only after 14 days from the last treatment. .

Xylazine is an alpha adrenoceptor agonist acting primarily on alpha-2 receptors. Precautions should be taken to avoid accidental injection /self injection.

Wash splashes from skin and eyes immediately.

In the event of accidental injection/self-injection, seek urgent medical advice and show label and other product literature. DO NOT DRIVE as sedation and changes in blood pressure may occur.

Xylazine is an alpha adrenoceptor agonist whose toxicity may cause clinical effects including sedation, respiratory depression and coma, bradycardia and hypotension and hyperglycaemia. Ventricular arrhythmias have also been reported. Treatment should be supportive with appropriate intensive therapy.

Environmental warnings

Unused product and containers should be disposed of in accordance with national requirements.

For animal treatment only. Keep out of the reach of children.