Introduction

Chanelle combined

Chanelle Vet UK Ltd

Address: CBX11 West Wing

382-390 Midsummer Boulevard

Milton Keynes, Bucks MK9 2RG

Telephone: 01908 843636

Fax: 01908 847401

Website: www.chanellevetuk.com

Company name: Chanelle Animal Health Limited

7 Rodney Street

Liverpool

L1 9HZ

Tel & Fax: 01568 750432

Website: www.chanellegroup.ie

Presentation

A clear, colourless aqueous solution for injection. Each ml of Chanazine 10% contains 100 mg xylazine base.

Uses

Chanazine 10% is a sedative with analgesic and muscle relaxant properties for use in horses only in many cases where sedation is required, including:

1.Handling fractious animals e.g. for transportation.

2.Medical examinations e.g. X-ray examination, removal of bandages, examination of the penis and oral cavity.

3.Premedication for minor superficial operations and local or regional anaesthesia.

4.Elimination of defaecation when examining and treating the vagina, uterus and hindquarters.

Dosage and administration

Chanazine 10% is given by slow intravenous injection. Dosage is dependent on the degree of sedation required and the response of the animal, and is (0.5 - 1 mg/kg) bodyweight. Nervous or excitable horses may require higher doses. Older horses and those having undergone severe physical exertion before treatment should receive the lowest dose rate. Animals do not usually become recumbent after administration and light to deep sedation with a variable degree of analgesia is obtained. Effects are usually seen within 5 minutes and persist for approximately 20 minutes. Chanazine 10% may be employed as a premedication to barbiturate anaesthesia or in combination with regional or local anaesthesia.

Contra-indications, warnings, etc

Not for use in horses intended for human consumption.

Do not administer by the intra-carotid route.

Careful consideration should be given before administering to animals exposed to stress conditions such as extreme heat, cold, high altitude or fatigue.

Side Effects such as bradycardia, cardiac arrhythmia and polyuria may occur.

Following intravenous administration, a transient rise followed by a fall in blood pressure usually occurs. Should be used with caution when pulmonary disease is suspected.

Sedation is dose dependent and the occurrence of side effects will increase and worsen at higher dosage than recommended.

Chanazine 10% should not be administered in the later stages of pregnancy because of the risk of inducing premature parturition. As the safety of xylazine use during organogenesis has not been fully demonstrated by current methods it should be used with caution during the first month of pregnancy.

General precautions

For animal treatment only. Keep out of reach of children.

Operator warnings

Horses sedated with Xylazine usually remain standing and may still kick with accuracy.

Xylazine is an alpha adrenoceptor agonist acting primarily on alpha-2 receptors. Precaution should be taken to avoid accidental injection/self-injection. Wash splashes from skin and eyes immediately. In the event of accidental injection/self-injection, seek urgent medical advice and show label and other product literature. DO NOT DRIVE as sedation and changes in blood pressure may occur.

Advice to Doctors

Xylazine is an alpha adrenoceptor agonist whose toxicity may cause clinical effects including sedation, respiratory depression and coma, bradycardia and hypotension and hyperglycaemia. Ventricular arrhy- thmias have also been reported. Treatment should be supportive with appropriate intensive therapy.

Environmental warnings

Unused product and containers should be disposed of in accordance with national requirements.