The product should not be used in breeding animals, or animals suffering from liver or renal diseases.

Adverse reactions: A transient hypotensive effect has been observed during the first 10 minutes post-injection of atipamezole hydrochloride. In rare cases hyperactivity, tachycardia, salivation, atypical vocalisation, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination and uncontrolled defecation may occur. In very rare cases recurrence of sedation may occur or the recovery time may not be shortened after administration of atipamezole.

In cats, when using low doses to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be guarded against.

If you notice any serious effects or other effects not mentioned in this data sheet, please inform your veterinary surgeon or pharmacist.

Special precautions for use in animals: After administration of the product, the animal should be allowed to rest in a quiet place. During recovery time the animal should not be left unattended. Due to different dosing recommendations caution should be taken if using the product off-label in animals other than the target species.

If sedatives other than medetomidine are given, it must be kept in mind that the effects of those other agents may persist after reversal of (dex)medetomidine.

Atipamezole does not reverse the effect of ketamine, which may cause seizures in dogs and elicit cramps in cats when used alone. Do not administer atipamezole within 30 – 40 minutes of prior administration of ketamine.

Special precautions to be taken by the person administering the veterinary medicinal product to animals: Due to the potent pharmacological activity of atipamezole, skin, eye and mucous membrane contact with this product should be avoided. In case of accidental contact of the product with skin or eyes rinse abundantly with fresh water. Seek medical attention if irritation persists. Remove contaminated clothes that are in direct contact with the skin. Care should be taken to avoid accidental ingestion or self-injection. In case of accidental oral intake or self-injection, seek medical advice immediately and show the data sheet to the physician.

Use during pregnancy and lactation: The safety of the product has not been documented adequately during pregnancy and lactation. Therefore use is not recommended during pregnancy and lactation.

Interactions with other medicinal products and other forms of interaction: A simultaneous administration of atipamezole with other centrally acting medicinal products, such as diazepam, acepromazine or opiates is not recommended.

Overdose (symptoms, emergency procedures, antidotes): Overdose of atipamezole hydrochloride may result in transient tachycardia and over-alertness (hyperactivity, muscle tremor). If necessary, these symptoms may be reversed by a medetomidine hydrochloride dose which is lower than the usual clinical dose.

If atipamezole hydrochloride is inadvertently administered to an animal not previously treated with (dex)medetomidine hydrochloride, hyperactivity and muscle tremor may occur. These effects may persist for about 15 minutes.

General precautions: For animal treatment only.