For oral administration only.

The 5 mg tablet is suitable for cats requiring higher dose rates, or to facilitate compliance (see below).

In the light of recent studies, and following the introduction of a 2.5 mg tablet, it is recommended to use the 2.5 mg tablet for stabilisation in the first instance.

For the stabilisation of feline hyperthyroidism prior to surgical removal of the thyroid gland, one 2.5 mg tablet morning and evening. This should ensure euthyroidism within 3 weeks in most cases.

For long-term treatment of hyperthyroidism, the starting dose should be 2.5 mg twice daily. After 3 weeks, the dose should be titrated to effect according to the serum total T4. Dose adjustments should be made by increments of 2.5 mg. Wherever possible, the total daily dose should be divided into two and administered morning and evening. Tablets should not be split. The aim should be to achieve the lowest possible dose rate.

If, for reasons of compliance, once daily dosing with a 5 mg tablet is preferable, then this is acceptable although reduced efficacy can be expected compared to a twice daily regime. The 5 mg tablet is also suitable for cats requiring higher dose rates.

If more than 10 mg per day is required animals should be monitored particularly carefully. The dose administered must not exceed 20 mg/day.

For long-term treatment of hyperthyroidism the animal should be treated for life.

Haematology, biochemistry and serum total T4 should be assessed before initiating treatment and after 3 weeks, 6 weeks, 10 weeks, 20 weeks and thereafter every 3 months, and the dose titrated as necessary.