Gelofusine is given intravenously. The volume and the rate of administration will depend upon the condition of the animal, its species and body weight. In general the dose required is approximately equivalent to the calculated volume loss. The rate of administration can be increased by the application of pressure to the container or by use of a giving set pump. When given rapidly it should be warmed to no more than 37°C if possible. In severe acute blood loss a volume equivalent to 1 % of body weight may be given in 5-10 minutes until signs of hypovolaemia are relieved. When large volumes are infused, suitable monitoring should be employed to ensure that an adequate haematocrit is maintained (the haematocrit should not be allowed to fall below 25 %), and that dilutional effects upon coagulation are avoided (expert haematological advice should be sought especially in cases of massive blood loss).

For massive fluid loss, Gelofusine may be used concomitantly with blood, the rate and amount of which would depend upon the clinical condition of the animal. The haemodynamic status of the animal should be monitored.

If blood is to be given at the same time as Gelofusine it can be given through the same giving set since Gelofusine has a negligible Calcium content and therefore does not clot blood. Gelofusine can also be used to reconstitute packed red cells.