Dosage and administration
The recommended dosage of Oxyglobin is 30 ml/kg of body weight administered intravenously at a rate up to 10 ml/kg/hr. In certain clinical situations, a dosage of 15-30 ml/kg may be appropriate. The optimum dosage is based upon the degree and chronicity of the anaemia and the desired duration of the effect:
Pharmacokinetic parameters at multiple dose levels after a single infusion of Oxyglobin:
|
Dose
(ml/kg)
| Immediate post infusion plasma conc. (g/dl)*
| Duration (hours):
Oxyglobin
levels over
1 g/dl
| Cleared from plasma (days)**
|
15
| 2.0 – 2.5
| 23 – 39
| 4 – 6
|
21
| 3.4 – 4.3
| 66 – 70
| 5 – 7
|
30
| 3.6 – 4.8
| 74 – 82
| 5 – 9***
|
*range based on mean ± SD
**range based on 5 terminal half-lives
|
***range based on estimated mean value with bounds of a 95 % prediction interval
|
Remove overwrap prior to use. Use within 24 hours. Oxyglobin should be administered using aseptic technique via a standard intravenous infusion set and catheter. As with any intravenous fluid administration, Oxyglobin should be warmed to 37°C prior to administration. Do not microwave. Do not overheat.
Do not administer with other fluids or medicinal products concurrently via the same infusion set. Do not add medications or other solutions to the bag. Do not combine the contents of more than one bag.
Oxyglobin 130 mg/ml Solution for Infusion for Dogs: Dosage and administration
Date updated: 9 October 2008