Do not use in animals previously treated with Oxyglobin.

Plasma volume expanders, such as Oxyglobin, are contraindicated in dogs predisposed to circulatory overload with conditions such as oliguria or anuria, or advanced cardiac disease (i.e. congestive heart failure), or otherwise severely impaired cardiac function.

Oxyglobin is intended for single administration only.

During the clinical safety and efficacy study, adverse events were seen which may have been related to Oxyglobin and/or the underlying disease causing anaemia. Side effects which were observed included mild to moderate discolouration of the mucous membranes, sclera, and urine due to metabolism and/or excretion of haemoglobin. Effects commonly seen were vomiting, loss of appetite, fever, and circulatory overload with associated clinical signs such as tachypnea, dyspnea, harsh lung sounds, and pulmonary edema; circulatory overload was controlled by slowing the rate of administration. Occasionally noted effects were diarrhoea, discolouration of the skin, cardiac arrhythmias and very rarely nystagmus.

If you notice any other side effects, please inform your veterinary surgeon.

Concomitant treatment of the cause of the anaemia should be instituted.

The animal should not be over-hydrated prior to administration. Due to the plasma expanding properties of Oxyglobin, the possibility of circulatory overload should be considered especially when administering adjunctive intravenous fluids, particularly colloidal solutions. Signs of circulatory overload should be carefully monitored or central venous pressure (CVP) measured. If CVP increases to a clinically unacceptable level and/or if signs of circulatory overload are observed, the infusion of Oxyglobin should be temporarily discontinued and re-instituted at a slower rate when signs abate and/or CVP decreases.

Treatment with Oxyglobin results in a mild decrease in PCV (packed cell volume) immediately post infusion.

The safety and efficacy of Oxyglobin has not been evaluated in dogs with thrombocytopenia with active bleeding, oliguria or anuria, or advanced cardiac disease.

The safety of Oxyglobin for use in pregnant or lactating bitches has not been determined. The use in such animals is not recommended.

General precautions: For animal treatment only.