Chemistry: The presence of Oxyglobin in serum may interfere with colorometric readings and result in artifactual increases or decreases in the results of serum chemistry tests depending on the dosage administered, the time since infusion, the type of analyser and the reagents used (contact Dechra for specific data).

Haematology: No interference. Confirm that haemoglobin is measured, not calculated from red blood cell number.

Coagulation: Prothrombin time (PT) and activated partial thromboplastin time (aPPT) can be accurately determined using methods that are mechanical, magnetic, and light scattering. Optical methods are not reliable for coagulation assays in the presence of Oxyglobin.

Urinalysis: Sediment examination is accurate. Dipstick measurements (i.e. pH, glucose, ketones, protein) are inaccurate while gross discolouration of the urine is present.

Marketing authorisation holder: Biopure Netherlands B.V., Parnassustoren / Locatellikade 1, NL-1076 AZ Amsterdam, The Netherlands.

Manufacturer for the batch release: Dales Pharmaceuticals, Snaygill Industrial Estate, Keighley Road, Skipton, North Yorkshire, BD23 2RW, UK.