Do not use in pregnant animals, those suffering from diabetes mellitus, in animals with renal insufficiency or those with corneal ulceration.

Do not use in animals being vaccinated with products containing live organisms. Treatment may render concurrent vaccination inoperative.

Appropriate therapy should be instituted in animals with concurrent bacterial infections. Use of corticosteroids may exacerbate viral infections.

Prolonged use at high dose levels may result in undesirable effects. Do not withdraw corticosteroid therapy suddenly.

Signs of overdosage should be treated symptomatically. Serum electrolytes should be monitored. Consideration should be given to the use of antimicrobials due to the potential suppression of the immune system.

Corticosteroids, including Prednisolone, have a wide range of effects. Polydipsia, polyuria and polyphagia may develop, particularly during the early stages of therapy. In the longer term, iatrogenic Cushing’s disease may develop.

Gastrointestinal ulceration has been reported in animals treated with corticosteroids. Steroids may cause enlargement of the liver (hepatomegaly) with increased serum hepatic enzymes.

Corticosteroid therapy may lead to increased time in the healing of wounds and to a reduction in the ability of the body to resist infection. Appropriate anti-infective therapy may be required.

Pharmacologically active dose levels may lead to atrophy of the adrenal cortex, resulting in adrenal insufficiency. This may become apparent particularly after withdrawal of corticosteroid treatment. Adrenal insufficiency may be minimised by institution of alternate-day therapy, if practical. The dosage should be reduced and withdrawn gradually to avoid precipitation of adrenal insufficiency.

Corticosteroids are not recommended for use in pregnant animals. Studies in laboratory animals have shown that administration during early pregnancy may cause foetal abnormalities. Administration during the later stages of pregnancy may cause abortion or early parturition.

Gastrointestinal ulceration may be exacerbated by corticosteroids in animals given non-steroidal anti-inflammatory drugs (NSAIDs).

Regular veterinary re-evaluation of animals on prolonged courses of Prednisolone is recommended.

Operator warnings: In the event of accidental ingestion, particularly by a child, seek medical advice and show the doctor the label or the package insert.

General precautions: For animal treatment only.